| 抗病毒1号中药有效部位体外对乙型流感病毒的抑制作用 |
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| 引用本文： | 常曼丽,李洪源,刘电力,佟奎明,周昆.抗病毒1号中药有效部位体外对乙型流感病毒的抑制作用[J].黑龙江医药,2002,15(1):15-17. |
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| 作者姓名： | 常曼丽 李洪源 刘电力 佟奎明 周昆 |
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| 作者单位： | 哈尔滨医科大学公卫学院，150001 |
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| 摘 要： | 为开发研制安全有效的抗流感病毒新药,本研究采用细胞培养技术,以病毒唑为阳性对照药,观察抗病毒1号中药有效部位(ADl)在MDCK细胞中对乙型流感病毒的抑制作用。结果表明ADl半数中毒浓度(TC_(50))为19.8mg/ml;抗乙型流感病毒的半数有效浓度(EC_(50))为1.47mg/ml;治疗指数(TI)为13.5;染毒后0-8小时分别给药均能抑制病毒增值,且对乙型流感病毒的抑制作用存在明显的量效反应关系。
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| 关 键 词： | 流感病毒 抗病毒作用 有效部位 |
| 修稿时间： | 2001年10月12 |
The Anti—influenza B virus Effect of an Active Compound from a Chinese Medicinal Herb—No1 |
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| Chang Manli.The Anti—influenza B virus Effect of an Active Compound from a Chinese Medicinal Herb—No1[J].Heilongjiang Medicine,2002,15(1):15-17. |
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| Authors: | Chang Manli |
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| Institution: | Chang Manli,Department of Epidemiology,Harbin Medical University 150001 |
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| Abstract: | To develop new safe and effective anti-influenza agents we observed the anti-vi- ral effect of an Active Compound from a Chinese Medicinal Herb-N01 by means of the technique of MDCK cell culture using Ribavirin as positive control. In MDCK culture, AD1 was found to be a inhibitor of influenza B virus in a concentration-dependent manner with TC_(50) of 19.8mg/ml. EC_(50) of 1.47mg/ml and TI of13.5; ADI had anti-influenza B virous effect while drug was added 1 -8h post infection. |
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| Keywords: | influenza virus antiviral effect active compound |
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