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中国南海总合草苔虫抗癌活性成分研究(IV)Bryostatin 8,16的分离与结构鉴定
引用本文:林厚文,姚新生,等.中国南海总合草苔虫抗癌活性成分研究(IV)Bryostatin 8,16的分离与结构鉴定[J].中国海洋药物,2001,20(4):1-6.
作者姓名:林厚文  姚新生
作者单位:[1]第二军医大学长征医院药学部,上海200003 [2]沈阳药科大学,沈阳110015
基金项目:国家自然科学基金资助项目(编号29672050)
摘    要:以体外抗癌活性为指标,采用多种层析分离技术,从采自广东大鹏湾海域的总合草苔中追踪分离得到8个活性单体。利用电喷雾离子质谱(ESI-MS)和高分辨(600MHz)核磁共振二 维谱技术测定活性化合成物的结构,分别鉴定为:bryostatin4,bryostatin5,bryostatin6,bryostatin8,bryostatin10,bryostatin11,bryostatin16,brytostatin18。其中,bryostatin8(I)和bryostatin16(Ⅱ)是首次从南海总合草苔虫中获得,并在体外表现出显著的抗癌活性。

关 键 词:总合草苔虫  草苔虫内酯  抗癌活性  Bryostatin8  16
文章编号:1002-3461(2001)04-0001-06
修稿时间:2001年1月17日

Studies on antineoplastic constituents from marine bryozoan bugula neritina inhabiting south china sea (IV):Isolation and structural elucidation of bryostatins 8 and 16
LIN Hou wen,YI Yang hu,YAO Xin sheng,WU Hou ming.Studies on antineoplastic constituents from marine bryozoan bugula neritina inhabiting south china sea (IV):Isolation and structural elucidation of bryostatins 8 and 16[J].Chinese Journal of Marine Drugs,2001,20(4):1-6.
Authors:LIN Hou wen  YI Yang hu  YAO Xin sheng  WU Hou ming
Abstract:Eight active compounds were isolated from Bugula neritina Linnaeus collected off Dapen Bay in Guandong province, guided by P 388 bioassay system by a combination of successive chromatographies and preparative HPLC. By intensive analysis of the data of high resolution 2D NMR spectrum and ESI MS, their structures were elucidated as known bryostatins--bryostatin 4, 5, 6, 8, 10, 11, 16 and 18, among which bryostatin 8 and 16 were for the first time obtained from this animal in South China Sea and they showed significant antineoplastic activities in vitro.
Keywords:Bugula neritina  Bryostatins  Antineoplastic agents
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