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| 发形霞水母触手提取物活性的初步研究 | |
| 引用本文： | 肖良,郭玉峰,张静,贺茜,聂菲,李玥,叶小飞,张黎明.发形霞水母触手提取物活性的初步研究[J].中国海洋药物,2008,27(5). |
| 作者姓名： | 肖良 郭玉峰 张静 贺茜 聂菲 李玥 叶小飞 张黎明 |
| 作者单位： | 1. 第二军医大学海医系防化医学教研塞.上海,200433 2. 第二军医大学药学院药理学教研室,上海,200433 3. 第二军医大学长海医院妇产科,上海,200433 4. 第二军医大学卫生勤务学系卫生统计学教研室.上海,200433 |
| 基金项目： | 全军专项项目，上海市自然科学基金，第二军医大学校科研和教改项目 |
| 摘 要： | 目的 初步分离发形霞水母触手提取物并探讨其生物学活性.方法采用自溶、离心的方法去除发形霞水母触手刺丝囊并获取触手提取物.通过阶段梯度阳离子交换色谱,应用0%.20%,40%,100%B液4种比例洗脱液将触手提取物分成4个组分,分别观察分离各组分的溶血、心血管等活性,并与触手提取物平行对比分析.结果成功分离到具有溶血、心血管活性的发形霞水母触手提取物,4个洗脱组分中,0%B液组分无上述3种活性,20%B液组分具有溶血活性、40%B液组分具有心血管活性,而100%B液组分则含有色素.结论通过阳离子交换色谱.初步将发形霞水母触手提取物中具有溶血活性、心血管活性以及色素等组分分离开来.为后续进一步纯化其单一活性组分打下基础. |
| 关 键 词： | 发形霞水母 触手提取物 溶血活性 心血管活性 |
Bioactive analysis of tentacle-only extract from jellyfish Cyanea capillata |
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| XIAO Liang,GUO Yu-feng,ZHANG Jing,HE Qian,NIE Fei,LI Yue,YE Xiao-fei,ZHANG Li-ming.Bioactive analysis of tentacle-only extract from jellyfish Cyanea capillata[J].Chinese Journal of Marine Drugs,2008,27(5). | |
| Authors: | XIAO Liang GUO Yu-feng ZHANG Jing HE Qian NIE Fei LI Yue YE Xiao-fei ZHANG Li-ming |
| Institution: | XIAO Liang1,GUO Yu-feng1,ZHANG Jing2,HE Qian3,NIE Fei1,LI Yue1,YE Xiao-fei4,ZHANG Li-ming1*(1.Department of Chemical Defense Medicine,Faculty of Naval Medicine,Second Military Medical University,Shanghai 200433,China,2.Department of Pharmacology,School of Pharmacy,3.Department of Gynecology , Obstetrics,Changhai Hospital,Second Military Medical University Shanghai 200433,4.Department of Health Statistics,Faculty of Health Services,Second Milit... |
| Abstract: | Objective To separate tentacle-only extract of jellyfish Cyanea capillata and explore its bioactivities.Methods Tentacle-only extract was obtained by autolysis and centrifugation,and the precipitation was removed.Tentacle-only extract was divided into four groups by gradient cation exchange chromatography,with proportions of B fluid 0%,20%,40%,100% respectively.Haematolysis and cardiovascular activities were determined for each component and compared with tentacle-only extract.Results Tentacle-only extract,... |
| Keywords: | jellyfish Cyanea capillata tentacle-only extract haematolysis cardiovascular activity |
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