仙葛颗粒对去卵巢骨质疏松大鼠模型的影响

目的观察仙葛颗粒对去卵巢骨质疏松大鼠模型的影响,探究其防治骨质疏松症的机制。方法将60只雌性大鼠随机分成空白对照组,模型组,仙葛颗粒低、中、高剂量组,尼尔雌醇组共6组。采用卵巢切除的方法制成绝经后骨质疏松动物模型,灌胃给药3个月后测定股骨骨密度及降钙素、骨钙素、雌二醇含量,取股骨下段松质骨进行电镜观察。结果仙葛颗粒能明显提高去卵巢大鼠模型血清降钙素、骨钙素和雌二醇水平,显著增加其骨密度值,改善松质骨的微结构。结论仙葛颗粒对骨质疏松症有防治作用。

Effect of Xiange Granule on osteoporosis in ovariectomized rat model

Purpose To observe the effect of Xiange Granule on osteoporosis in ovariectomized rat model and explore the mechanism of prevention and treatment of osteoporosis.Methods 60 female rats were randomly divided into blank control group, model group, Xiange Granule low, middle and high-dose group, CEE3 group of 6 groups. The method used ovariectomy made animal model of postmenopausal osteoporosis. Gavage after 3 months measured femur bone mineral density, calcitonin, bone gla protein and estradiol concentration, observed cancellous bone of femur with electron microscope.Results Xiange Granule could significantly increase the bone mineral density, calcitonin, bone gla protein and estradiol levels of the ovariectomized rat model and improve the microstructure of cancellous bone.Conclusion Xiange Granule is effective for prevention and treatment on osteoporosis.