| 甲壳素对双氯灭痛缓释片溶出的影响 |
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| 引用本文： | 伍茂福,李德平.甲壳素对双氯灭痛缓释片溶出的影响[J].中国生化药物杂志,1995,16(4):168-170. |
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| 作者姓名： | 伍茂福 李德平 |
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| 作者单位： | 南京总医院金陵药物研究所!南京210002 |
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| 摘 要： | 以pH 6.8磷酸盐缓冲液为释放介质,采用转蓝法测定了不同甲壳素含量的双氯灭痛缓释片的体外累体释放度。结果表明,随着片剂中壳素含量的增高、片剂溶出变慢,且溶出越符合零级释放。
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| 关 键 词： | 甲壳素 双氯灭痛 缓释 溶出 |
Effect of Chitin on Dissolution of Sustained Release Tablet of Diclofenac Sodium |
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| Wu Maofu,Li Deping,Liu Suqing,Zhang ZhihuiThe Pharmaceutical Research Institute of Jinling Hospital.Effect of Chitin on Dissolution of Sustained Release Tablet of Diclofenac Sodium[J].Chinese Journal of Biochemical Pharmaceutics,1995,16(4):168-170. |
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| Authors: | Wu Maofu Li Deping Liu Suqing Zhang ZhihuiThe Pharmaceutical Research Institute of Jinling Hospital |
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| Institution: | Nanjing 210002 |
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| Abstract: | The accumulative dissolution rates of five kinds of sustained release tablets of diclofenac sodium with different chitin content were detected in vitro at 37 C by rotation-basket method. The rotational speed was 100 r/min and the dissolvent was phosphate buffer (pH 6. 8). The results showed the tablets dissolution were slower and approached zero-order release with chitin content increasing. |
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| Keywords: | Chitin: Diclofenac sodium Sustained release Dissolution |
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