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| 静脉注射用人免疫球蛋白二级结构分析与生物学活性间的关系 | |
| 引用本文： | 王箐舟,程雅琴,沈世杰,杨圣鱼.静脉注射用人免疫球蛋白二级结构分析与生物学活性间的关系[J].中国生化药物杂志,2006,27(2):99-101. |
| 作者姓名： | 王箐舟 程雅琴 沈世杰 杨圣鱼 |
| 作者单位： | 1. 中国药品生物制品检定所,北京,100050 2. 军事医学科学院,仪器中心,北京,100854 3. 中国科学院,生物物理研究所,北京,100101 |
| 摘 要： | 目的对不同工艺生产的静脉注射用人免疫球蛋白(IVIG)的二级结构进行分析研究,优化生产工艺。方法采用圆二色谱和傅里叶变换红外光谱方法。结果不同工艺生产的IVIG制品β折叠含量不同。结论不同工艺生产的IVIG制品二级结构的差异影响了制品的生物学活性。 |
| 关 键 词： | 静脉注射用人免疫球蛋白 圆二色谱 傅里叶变换红外光谱 二级结构 |
| 文章编号： | 1005-1678（2006）02-0099-03 |
| 收稿时间： | 2005-06-20 |
| 修稿时间： | 2005-06-202005-10-13 |
The relationship between the secondary structures and biological activity of human intravenous immunoglobulin preparations |
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| WANG Qing-zhou,CHENG Ya-qin,SHEN Shi-jie,YANG Shen-yu.The relationship between the secondary structures and biological activity of human intravenous immunoglobulin preparations[J].Chinese Journal of Biochemical Pharmaceutics,2006,27(2):99-101. | |
| Authors: | WANG Qing-zhou CHENG Ya-qin SHEN Shi-jie YANG Shen-yu |
| Institution: | 1. National Institute for the Control of Pharmaceutical and Biological Products, Beifing 100050, China ; 2. Instrumental Analysis Center of Academy of Military Medical Sciences, Beijing 100854, China ; 3. Institute of Biophysics, Chinese Academy of Sciences, Beijing 100050, China |
| Abstract: | PurposeTo study secondary structures of human intravenous immunoglobulin preparations(IVIG) by various product technologies and by optimizing the product technology.Methodscircular dichroism(CD) and Fourier-transform infrared(FT-IR).ResultsThe β-folds of the different IVIG preparations are various.ConclusionSecondary structures of different IVIG preparations are changed and the biological activities are affected. |
| Keywords: | human intravenous immunoglobulin infrared secondary structure preparation circular dichroism fourier-transform |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |