Anti-inflammatory Effect and Toxicology Analysis of Oral Delivery Quercetin Nanosized Emulsion in Rats |
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Authors: | Gabriela Hädrich Gustavo Richter Vaz Michelle Maidana Jadel Muller Kratz Gecioni Loch-Neckel Daniely Cornélio Favarin Alexandre de Paula Rogerio Jr" target="_blank">Flávio Manoel Rodrigues da SilvaJr Ana Luiza Muccillo-Baisch Cristiana Lima Dora |
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Institution: | 1.Laboratório de Nanotecnologia Aplicada à Saúde, Programa de Pós-Gradua??o em Ciências da Saúde,Universidade Federal do Rio Grande (FURG),Rio Grande,Brazil;2.Laboratório de Ensaios Farmacológicos e Toxicológicos, Instituto de Ciências Biológicas,Universidade Federal do Rio Grande (FURG),Rio Grande,Brazil;3.Laboratório de Virologia Aplicada, Departamento de Ciências Farmacêuticas,Universidade Federal de Santa Catarina, Campus Universitário Trindade,Florianópolis,Brazil;4.Laboratório de Farmacotécnica, Departamento de Ciências Farmacêuticas,Universidade Federal de Santa Catarina, Campus Universitário Trindade,Florianópolis,Brazil;5.Laboratório de Imunofarmacologia experimental, Departamento de Clínica Médica,Universidade Federal do Triangulo Mineiro,Uberaba,Brazil |
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Abstract: | PurposeThis study evaluates the advantage of the quercetin encapsulation in nanosized emulsion (QU-NE) administered orally in rats in order to demonstrate its anti-oedematous and antioxidant effects as well as its toxicity.MethodsThe nanocarriers were prepared using the hot solvent diffusion with the phase inversion temperature methods. The nanocarriers physicochemical properties were then investigated. The anti-edematous activity was tested using paw edema in rats. In addition, NF-kB expression in subcutaneous tissue of the paws was accessed by immunohistochemistry while the lipid peroxidation was analyzed in the liver by malondialdehyde reaction with thiobarbituric acid. Hematological, renal and hepatic toxicity as well as the genetic damage were also evaluated.ResultsThe results demonstrated that QU-NE exhibited pronounced anti-oedematous property comparable to drug diclofenac. This effect was associated with NF-κB pathway inhibition. The lipid peroxidation was also only reduced in rats treated with QU-NE. Besides this, no genetic damage, hematological, renal or hepatic toxicities were observed after administration of QU-NE.ConclusionsThese results suggest that quercetin nanosized emulsion exhibits anti-oedematous and antioxidant properties and does not demonstrate toxic effects. This indicates that it has a potential application in the treatment of inflammatory diseases. |
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