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Drug Distribution in Brain and Cerebrospinal Fluids in Relation to IC50 Values in Aging and Alzheimer’s Disease,Using the Physiologically Based LeiCNS-PK3.0 Model |
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| Authors: | Saleh Mohammed A A Bloemberg Julia S Elassaiss-Schaap Jeroen de Lange Elizabeth C M |
| Institution: | 1.Division of Systems Pharmacology and Pharmacy, Leiden Academic Center for Drug Research, Leiden University, Leiden, The Netherlands ;2.PD-value B.V., Houten, The Netherlands ; |
| Abstract: | Pharmaceutical Research - Very little knowledge exists on the impact of Alzheimer’s disease on the CNS target site pharmacokinetics (PK). To predict the CNS PK of cognitively healthy young... |
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