我院2005年临床分离菌菌群分布及耐药分析

目的:了解我院临床分离菌的分布及耐药情况,为指导临床合理用药提供参考依据.方法:采用Vitek-2全自动微生物分析仪及纸片扩散法(Kirby-Bauer)对2 024株分离菌进行鉴定及药敏实验.结果:2024株分离菌中革兰阴性菌占53.6%,革兰阳性菌占36.0%,真菌占10.4%,金黄色葡萄球菌及凝固酶阴性的葡萄球菌中甲氧西林耐药株各占30.2%和34.4%.革兰阳性球菌中万古霉素抗菌活性最强,粪肠球菌对万古霉素耐药率为1.7%.革兰阴性杆菌中亚胺培南抗菌活性最强,铜绿假单胞菌对其有4.6%的耐药率;大肠埃希菌及肺炎克雷伯菌超广谱β-内酰胺酶的检出率为65.0%和40.0%.结论:本资料对临床治疗及抗生素药物的选用有参考价值.

Analysis of Bacterial Distribution and Drug Resistance in the 252nd Hospital of PLA in the Year 2005

Objective:To Analyze the bacterial distribution and resistance in the 252nd Hospital so as to advise the dosage in clinical practice.Methods:The identification of bacteria and susceptibility test were performed using automatic bioanalysis-Vitek-2 and Kirby-Bauer methods.Results:Of 2 024 clinical isolates,gram negative organisms accounted for 53.6%,gram positive organisms for 36.0%,and eumycete for 9.5%.In staphylococuus aureus(MRSA) and coagulase negative Staphylococuus,MRSA and MRCNS accounted for 30.2% and 34.4% respectively.Vancomycin is the most potent antimicrobial agent against gram positive organisms with the resistant rate of Enterococcus faecalis at 1.7%.Imipenem is the most potent antimicrobial agent against gram negative bacilli with the resistant rate of Pseudomonas aeruginosa at 4.6%.The detection rate of Escherichia coli and Klebsiella pneumoniae were 65.0% and 40.0% respectively in ESBLs.Conclusion:The results can be helpful in reasonable choosing of antimicrobial agents in the treatment of infection caused by pathogenic bacteria.