| 益气活血中药的毒性实验研究 |
| |
| 引用本文： | 张晓敏,王炳胜,葛艳丽,张建宇.益气活血中药的毒性实验研究[J].华北国防医药,2011,23(4). |
| |
| 作者姓名： | 张晓敏 王炳胜 葛艳丽 张建宇 |
| |
| 作者单位： | 1. 石家庄市第三医院药剂科,石家庄,050011
2. 张家口,解放军251医院肿瘤诊疗中心,河北,075000 |
| |
| 基金项目： | 全军"十一五"课题基金资助项目 |
| |
| 摘 要： | 目的 观察益气活血中药对正常小鼠的毒性作用.方法 取健康小鼠120只,随机分为78 g/kg剂量组、156 g/kg剂量组、312 g/kg剂量组和对照组,每组30只.不同剂量组分别予相应剂量益气活血中药灌胃,对照组予0.9%氯化钠注射液灌胃.观察不同组用药前,给药1、2、3个月及停药后2周一般情况,并于给药后3个月及停药后2周采血测定血液学及生化指标,同时对其肝、肾和胃等组织结构进行病理学检查.结果 给药期间不同剂量组和对照组一般情况均未发现异常.给药前,给药1、2、3个月及停药后2周不同剂量组体重与对照组比较差异均无统计学意义(P＞0.05).给药后3个月及停药后2周,不同剂量组血液学及生化指标与对照组比较差异亦均无统计学意义(P＞0.05);处死小鼠病理学检查结果示心、肝、脾、肺、肾、胃、小肠及性腺等组织结构均未发现明显异常.结论 益气活血中药口服安全,长期使用无毒副作用.
|
| 关 键 词： | 益气活血中药 毒性试验 小鼠 |
Chronic Toxicity Test of Yiqihuoxue Recipe |
| |
| ZHANG Xiao-min,WANG Bing-sheng,GE Yan-li,ZHANG Jian-yu.Chronic Toxicity Test of Yiqihuoxue Recipe[J].Medical Journal of Beijing Military Region,2011,23(4). |
| |
| Authors: | ZHANG Xiao-min WANG Bing-sheng GE Yan-li ZHANG Jian-yu |
| |
| Institution: | ZHANG Xiao-min1,WANG Bing-sheng2,GE Yan-li2,ZHANG Jian-yu2(1.Pharmaceutical Preparation Center,the Third Hospital of Shijiazhuang City,Shijiazhuang 050011,China,2.Tumor Treatment and Diagnosis Centre,the 251st Hospital of PLA,Zhangjiakou,Hebei 075000,China) |
| |
| Abstract: | Objective To study the chronic toxicity of Yiqihuoxue recipe in mice to provide necessary theretical basis for its clinical application.Methods 120 healthy mice were randomly divided into low dose group(78 g/kg),medium dose group(156 g/kg),high dose group(312 g/kg) and control group(0.9% sodium chloride injection),with 30 in each.The major conditions in all the groups before treatment and during the 1st,2nd and 3rd month of treatment and 2 weeks after drug discontinuance were observed.Hematology and biochem... |
| |
| Keywords: | Yiqihuoxue recipe Toxicity test Mouse |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
