| 纳米级与微米级珍珠粉对大鼠深Ⅱ度烫伤的药效学评价 |
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| 引用本文： | 杨莉,田吉来,柯学.纳米级与微米级珍珠粉对大鼠深Ⅱ度烫伤的药效学评价[J].临床医药实践,2012,21(4):281-284. |
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| 作者姓名： | 杨莉 田吉来 柯学 |
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| 作者单位： | 1. 中国人民解放军南京空军机关医院,江苏南京,210018
2. 中国药科大学药学院,江苏南京,210009 |
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| 摘 要： | 目的:比较纳米级与微米级珍珠粉对大鼠烫伤皮肤的愈合效果。方法:建立大鼠深Ⅱ度烫伤模型;分别以纳米级珍珠粉高低剂量(30 m g/d,10 m g/d)、微米级珍珠粉高低剂量(30 m g/d,10 m g/d)以及阳性和阴性对照共6组进行对比治疗,测量第3天,第7天和第14天伤痕面积以及各组的痊愈时间;并采用配对t检验法对数据进行统计分析。结果:纳米级珍珠粉对烫伤皮肤的治疗效果要显著优于相应的微米级珍珠粉;纳米级高剂量组(30 m g/d)效果最好,与阳性药物相当;纳米级低剂量组(10 m g/d)的疗效与微米级高剂量组(30 m g/d)相当。结论:珍珠粉纳米化后能显著提高其对烫伤的治疗效果。
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| 关 键 词： | 珍珠粉 纳米级技术 烫伤模型 配对t检验 |
Pharmacodynamic evaluation of nano or micro pearl powder on the partial-thickness wurn wound in rats |
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| YANG Li
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TIAN Ji-lai
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KE Xue.Pharmacodynamic evaluation of nano or micro pearl powder on the partial-thickness wurn wound in rats[J].Proceeding of Clinical Medicine,2012,21(4):281-284. |
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| Authors: | YANG Li TIAN Ji-lai KE Xue |
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| Institution: | 1.Air Force Authorities Hospital of Chinese People′s Liberation Army in Nanjing,Nanjing 210018,China;2.Pharmacy College of China Pharmaceutical University,Nanjing 210009,China) |
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| Abstract: | Objective:To assess the effect on scald of SD rats between nano and micro pearl powder.Methods:The deepⅡ scald model of SD rats was established.The scalded skin was treated with the nano pearl powder(30 mg/d and 10 mg/d),the micro pearl powder(30 mg/d and 10 mg/d),positive control and negative control.The scar area at 3rd,7nd and 14nd day was measured and the concrescence time was recorded.Then the data was analyzed with paired t-test.Results:The groups of nano pearl powder was more effective than that of corresponding micro pearl powder on scalded skin remarkably.Nano pearl powder(30 mg/d) showed the best curative effect within groups and similar with the positive control.The nano pearl powder(10 mg/d) showed the similar curative effect with the micro pearl powder(30 mg/d).Conclusion:The curative effect of the scald could be enhanced by using nano pearl powder. |
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| Keywords: | pearl powder nanotechnology scald model paired ttest |
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