黄芪注射液对大鼠肝损伤的保护作用

目的 :探讨黄芪注射液 (HQI)对大鼠实验性肝损伤的保护作用。方法 :采用硫代乙酰胺所致肝损伤模型 ,并测定肝功能 ,肝组织学检查及肝组织血浆和血清脂质过氧化测定。结果 :硫代乙酰胺模型组 2 4 h后大鼠血清 GPT为(1110 .0± 15 2 .5 ) U/10 0 m L,显著高于正常对照组 (P<0 .0 1)。HQI低、中、高剂量组大鼠血清 GPT分别为 (788.3±75 .3) U/10 0 m L、(76 0 .7± 6 7.7) U/10 0 m L、(5 17.1± 6 2 .2 ) U/10 0 m L,均显著低于模型组 (P<0 .0 1)。HQI治疗组肝组织和血清 MDA浓度显著低于模型组 ;病理学改变显著。结论 :HQI0 .5 g/kg～ 4 g/kg可对抗硫代乙酰胺引起的大鼠肝脏损伤 ;本实验结果提示 ,HQI具有减少脂质过氧化物产生的作用

Protective effects of Astragalus Injection on experimental liver lesion

Objective:The present experiments were designed to study the protective effects of Astragalus injection (Huang Qi injection HQI) on thioacetamide-induced rat liver lesion and to study effect of HQI on production of lipid hyperoxided.Methods:Rats in HQI-treated group were injected with HQI 0.5～4 g/kg once a day for 5 days before igthioacetmaide 250 mg/kg.Results:At 24 hours after ig thioacetamide,blood GPT level in HQI-treated groups were 788.3±75.3,760.7±67.7,517.1±62.2 U/100 mL respectively,significantly lower than model group(1110.0±152.5 U/100 mL).Liver and serum concentrations of MDA were lower in HQI-treated groups.Histologic finding indicated that HQI-treated groups had much slighter lesion compared with the model group.Conclusion:The present results indicate that HQI,at doses of 0.5～4 g/kg,lightens thioacetamide inducedrat liver damage;in addition HQI also decreases the production of lipid hyperoxides.