| 氟伐他汀对高糖诱导人足细胞血管内皮生长因子表达的影响及机制 |
| |
| 引用本文： | 赵鲁米,刘佳,孙彬,赵秀芬,钱军,邢昌赢,王笑云.氟伐他汀对高糖诱导人足细胞血管内皮生长因子表达的影响及机制[J].江苏医药,2011,37(15). |
| |
| 作者姓名： | 赵鲁米 刘佳 孙彬 赵秀芬 钱军 邢昌赢 王笑云 |
| |
| 作者单位： | 南京医科大学第一附属医院肾脏病科,210029 |
| |
| 基金项目： | 江苏省卫生厅科研基金(H200317) |
| |
| 摘 要： | 目的探讨氟伐他汀对高糖诱导的人足细胞血管内皮生长因子(VEGF)表达的影响及机制。方法体外培养人足细胞,随机分为A组(正常糖组)、B组(高糖组)、C组(高糖+氟伐他汀10-7mol/L组)、D组(高糖+氟伐他汀10-6mol/L组)、E组(高糖+氟伐他汀10-5mol/L组)和F组高糖+胞外信号调节激酶(ERK)抑制剂PD98059组]。用Western blot检测VEGF和磷酸化ERK1/2(pERK1/2)蛋白表达。结果 B组VEGF、pERK1/2表达较A组明显升高,并呈时间依赖性(P<0.05)。F组VEGF、pERK1/2表达较B组显著降低(P<0.01)。与B组比较,C、D、E组VEGF及pERK1/2表达亦明显减少,并呈浓度依赖性(P<0.05)。结论高糖刺激体外培养人足细胞VEGF表达增加,氟伐他汀可减少高糖诱导的VEGF表达,其机制可能与氟伐他汀抑制ERK信号通路有关。
|
| 关 键 词： | 氟伐他汀 高糖 足细胞 血管内皮生长因子 胞外信号调节激酶信号通路 |
The effect and mechanism of fluvastatin on the expression of vascular endothelial growth factor in human podocytes induced by high glucose |
| |
| ZHAO Lumi,LIU Jia,SUN Bin,et al..The effect and mechanism of fluvastatin on the expression of vascular endothelial growth factor in human podocytes induced by high glucose[J].Jiangsu Medical Journal,2011,37(15). |
| |
| Authors: | ZHAO Lumi LIU Jia SUN Bin |
| |
| Institution: | ZHAO Lumi,LIU Jia,SUN Bin,et al.Department of Nephrology,First Affiliated Hospital,Nanjing Medical University,Nanjing 210029,CHINA |
| |
| Abstract: | Objective To investigate the effect and mechanism of fluvastatin on the expression of vascular endothelial growth factor(VEGF) in human podocytes induced by high glucose.MethodsHuman podocytes were randomly divided into six groups of A (normal glucose),B(high glucose),C(high glucose plus fluvastatin 10-7mol/L),D(high glucose plus fluvastatin 10-6mol/L),E(high glucose plus fluvastatin 10-5mol/L) and Fhigh glucose plus extracellular signal-regulated kinase(ERK) inhibitor PD98059].The expressions of VEGF and ... |
| |
| Keywords: | Fluvastatin High glucose Podocyte Vascular endothelial growth factor Extracellular signal-regulated kinase signal pathway |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
