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| 内皮素1及其受体在良性前列腺增生中的表达 | |
| 引用本文： | 许露伟,贾瑞鹏,温传俊,刘军,王劲松.内皮素1及其受体在良性前列腺增生中的表达[J].江苏医药,2006,32(7):618-619,i0001. |
| 作者姓名： | 许露伟 贾瑞鹏 温传俊 刘军 王劲松 |
| 作者单位： | 1. 210006,南京医科大学附属南京第一医院泌尿外科 2. 南京师范大学生命科学院 3. 210006,南京医科大学附属南京第一医院病理科 |
| 摘 要： | 目的 探讨内皮素1（ET-1）及其受体（ETAR与ETBR）在良性前列腺增生（BPH）移行区组织中表达的意义。方法 采用免疫组化及Western blot技术检测5例正常前列腺组织（NP）与16例良性前列腺增生组织中ET-1及其受体表达。结果 良性前列腺移行区组织中ET-1与ETAR表达明显高于正常前列腺组织。结论 ET-1及其ETAR参与了良性前列腺增生的病理生理过程。 |
| 关 键 词： | 良性前列腺增生 内皮素1 内皮素受体 |
| 收稿时间： | 2006-04-31 |
| 修稿时间： | 2006-04-31 |
Endothelin-1 and its receptors expression in prostatic tissues of patients with benign prostatic hyperplasia |
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| XU Luwei ,JIA Ruipeng, WEN Chuanjun, et al.Endothelin-1 and its receptors expression in prostatic tissues of patients with benign prostatic hyperplasia[J].Jiangsu Medical Journal,2006,32(7):618-619,i0001. | |
| Authors: | XU Luwei JIA Ruipeng WEN Chuanjun |
| Institution: | Department of Urology, Affiliated Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, CHINA |
| Abstract: | Objective To elucidate endothelin-1(ET-1) and its receptors expression in benign prostatic hyperplasia (BPH), and to explore the role of ET-1 in the pathogenesis of BPH.Methods The expression of ET-1 was detected by immunohistochemistry and the protein of ET_AR and ET_BR by Western blot in 16 samples of BPH and 5 samples of normal prostate.Results Positive ET-1 was detected in basal epithelial cells and secretory cells of the glandular epithelium of the samples of BPH. The expression of ET_AR of BPH was significantly higher than that of the control. Conclusion The effect of endothelin was prominently mediated by ET_A receptor.These results suggest that ET-1 and ET_AR may play a functional role in benign prostatic hyperplasia. |
| Keywords: | Benign prostatic hyperplasia Endothelin-1 Endothelin receptor |
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