| 银纳米颗粒增强磁流体热疗对脑胶质瘤C6细胞的杀伤作用 |
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| 引用本文： | 杨丰忠,张建超,王军,徐睿智.银纳米颗粒增强磁流体热疗对脑胶质瘤C6细胞的杀伤作用[J].江苏医药,2011,37(4). |
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| 作者姓名： | 杨丰忠 张建超 王军 徐睿智 |
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| 作者单位： | 1. 淮阴医院神经外科,淮安市,223300
2. 南京医科大学第一附属医院放疗科 |
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| 基金项目： | 国家自然基金项目(30970792) |
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| 摘 要： | 目的研究20 nm银纳米颗粒(AgNPs)对脑胶质瘤C6细胞磁流体热疗的作用。方法脑胶质瘤C6细胞分为对照组、AgNPs组、磁流体热疗组和AgNPs结合磁流体热疗组。通过集落形成实验检测20 nm AgNPs对脑胶质瘤C6细胞热疗的效果;流式细胞术检测AgNPs对细胞周期和凋亡率的影响;HE染色检测AgNPs对荷瘤鼠磁流体热疗凋亡的影响。结果与对照组比较,20 nmAgNPs能够引起脑胶质瘤C6细胞G2/M期阻滞,并使细胞在接受磁流体热疗后凋亡率显著提高(P<0.05)。结论银纳米颗粒能提高脑胶质瘤C6细胞的热敏感性。
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| 关 键 词： | 银纳米颗粒 磁流体热疗 |
Silver nanoparticles enhances the lethal effect of magnetic fluid hyperthermia on brain glioma C6 cells |
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| YANG Fengzhong,ZHANG Jianchao,WANG Jun,et al..Silver nanoparticles enhances the lethal effect of magnetic fluid hyperthermia on brain glioma C6 cells[J].Jiangsu Medical Journal,2011,37(4). |
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| Authors: | YANG Fengzhong ZHANG Jianchao WANG Jun |
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| Institution: | YANG Fengzhong,ZHANG Jianchao,WANG Jun,et al.Department of Neurosurgery,Huaiyin Hospital,Huaian 223300,CHINA |
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| Abstract: | Objective To investigate the effect of 20 nm silver nanoparticles(AgNPs) on brain glioma C6 cells after magnetic fluid hyperthermia.Methods Brain glioma C6 cells were divided into four groups of control,AgNPs,magnetic fluid hyperthermia and AgNPs combined with magnetic fluid hyperthermia.The effect of 20 nm AgNPs on thermotherapy of glioma C6 cells was detected by colony-forming assay.The cell cycle and apoptosis after irritation were tested by flow cytometry.HE staining was used to detect the effect of AgN... |
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| Keywords: | Silver nanoparticles Magnetic fluid hyperthermia |
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