| 急性心肌梗死患者血浆趋化因子受体CCR1表达 |
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| 引用本文： | 黄尧垚,汤成春,李拥军,马根山,冯毅,戴启明,沈成兴,陈忠,丁建东,章晓国,谢学玲.急性心肌梗死患者血浆趋化因子受体CCR1表达[J].江苏医药,2011,37(2). |
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| 作者姓名： | 黄尧垚 汤成春 李拥军 马根山 冯毅 戴启明 沈成兴 陈忠 丁建东 章晓国 谢学玲 |
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| 作者单位： | 1. 广东省汕头市中心医院心脏病科
2. 东南大学附属中大医院心脏病科,南京市,210009 |
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| 基金项目： | 江苏省医学重点人才基金(RC2007103) |
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| 摘 要： | 目的观察CC趋化因子受体1(CCR1)在急性心肌梗死(AMI)患者血浆中的表达水平。方法检测AMI组(29例)、不稳定型心绞痛(UAP)组(30例)、稳定型心绞痛(SAP)组(30例)和正常对照(C)组(25例)血常规、血脂、超敏C反应蛋白(hs-CRP)、心肌肌钙蛋白I(cTnI)、低密度脂蛋白胆固醇(LDL-C)、白细胞(WBC)、中性粒细胞比值(N),ELISA法检测血浆CCR1表达;动态观察AMI患者经皮冠状动脉介入治疗(PCI)术前、术后24、48h、5、7d的CCR1水平变化,分析CCR1与hs-CRP、cTnI、LDL-C、WBC、N比值的相关性。结果 AMI组、UAP组、SAP组血浆CRR1水平明显高于C组(3.72±0.94)ng/ml、(2.05±0.38)ng/ml、(1.82±0.41)ng/mlvs.(0.68±0.27)ng/ml](P<0.05);AMI组血浆CCR1水平明显高于UAP组、SAP组;AMI组患者PCI术前血浆CCR1水平显著高于术后(P<0.05);血浆CCR1水平与WBC、N比值呈正相关(P<0.05)。结论 AMI组患者CCR1水平明显升高,PCI术后逐渐下...
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| 关 键 词： | 急性心肌梗死 CC趋化因子受体1 |
Expression of plasma CCR1 in patients with acute myocardial infarction |
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| HUANG Yaoyao,TANG Chengchun,LI Yongjun,et al..Expression of plasma CCR1 in patients with acute myocardial infarction[J].Jiangsu Medical Journal,2011,37(2). |
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| Authors: | HUANG Yaoyao TANG Chengchun LI Yongjun |
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| Institution: | HUANG Yaoyao,TANG Chengchun,LI Yongjun,et al.Department of Cardiology,Affiliated Zhongda Hospital,Southeast University,Nanjing 210009,CHINA |
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| Abstract: | Objective To examine the plasma concentration of CC chemokine receptor 1(CCR1) in patients with acute myocardial infarction(AMI).Methods The plasma concentration of CCR1 was detected by ELISA and blood routine,lipids,high sensitive C-reactive protein(hs-CRP),calcitonin-I(cTnI) were examined in 29 AMI patients(group AMI),30 patients with unstable angina(group UAP),30 patients with stable angina(group SAP) and 25 control patients(group C).The relationship between CCR1 and coronary heart disease-related inflam... |
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| Keywords: | Acute myocardial infarction CC chemokine receptor 1 |
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