奥沙利铂治疗胃肠道肿瘤的不良反应及治疗方案分析

目的探究奥沙利铂治疗胃肠道肿瘤的不良反应及临床治疗方案比较。方法回顾性分析59例胃肠道肿瘤患者,治疗A组采用第1天给予奥沙利铂,第1～7天给予亚叶酸钙和5-氟尿嘧啶的治疗方案,治疗B组采用化疗前给予神经营养治疗、静脉滴注葡萄糖酸钙后再行第1天给予奥沙利铂,第1～7天给予亚叶酸钙和5-氟尿嘧啶的治疗方案,比较不同性别、年龄、原发肿瘤类型及治疗方案患者的不良反应发生情况。结果不同年龄、不同原发肿瘤类型患者的不良反应发生率比较,差异无统计学意义(P>0.05);不同性别患者神经毒性反应发生率比较,差异有统计学意义(P<0.05),不同治疗方案患者的神经毒性反应和过敏反应发生率比较,差异有统计学意义(P<0.05)。结论通过降低奥沙利铂的用药剂量以及加用葡萄糖酸钙和神经营养液等预防用药,可以降低患者的不良反应发生率,提高治疗效果。

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Objective The purpose is to explore the adverse reaction factors of oxaliplatin in the treatment of gastrointestinal tumor and to compare the effects of different clinical treatments. Methods Fifty-nine patients were divided into two groups. Patients in group A were given oxaliplatin on the first day, leucovorin and 5-fluorouracil on 1-7 days. Patients in group B were given nerve nutrition therapy and intravenous calcium gluconate before chemotherapy, then were given oxaliplatin on the first day and leucovorin and 5-fluorouracil on 1~7 days. The incidences of adverse reactions were compared between the two groups according to gender, age, primary tumor types and treatment options for patients. Results The adverse reaction incidence rates showed no significant differences between patients with different age and tumor types, P〉 0.05. The neurotoxicity reaction rates showed significant differences between patients with different genders, P〈0.05. The neurotoxicity and allergic reaction rates of patients with different treatment options showed significant difference, P〈0.05. Conclusion The incidence of adverse reaction of patients can be reduced and the therapeutic effects can be improved by reducing the dose of oxaliplatin and adding calcium glu- conate and neural nutrition or other preventive medicines as well.