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Methodological advances in the design of peptide-based vaccines |
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| Institution: | Molecular and Structural Biophysics Laboratory, Department of Biochemistry, North-Eastern Hill University, Shillong 793022, India |
| Abstract: | The tremendous advances in genomics, recombinant DNA technology, bioengineering and nanotechnology, in conjunction with the development of high-end computations, have been instrumental in the process of rational design of peptide-based vaccines. The use of peptide vaccines was limited owing to their inherent instability when systemically administered; however, advanced formulation techniques have been developed for their systemic delivery, thereby overcoming their degradation, clearance, cellular uptake and off-target effects. With the rise of sophisticated immunological predictors and experimental techniques, several methodological advances have occurred in this field. This review examines contemporary methods to identify and optimize epitopes, engineer their immunogenic properties and develop their safe and efficient delivery into the host. |
| Keywords: | Adjuvants Epitopes Immunoinformatics Reverse vaccinology Peptide vaccine Vaccine design Immunogenicity Immune response Subunit APCs"} {"#name":"keyword" "$":{"id":"pc_axYoar7RqF"} "$$":[{"#name":"text" "_":"Antigen-presenting cells CD8/CD4"} {"#name":"keyword" "$":{"id":"pc_hwGQtmbIgW"} "$$":[{"#name":"text" "_":"Cluster of differentiation 8 or 4 DCs"} {"#name":"keyword" "$":{"id":"pc_ajdHCYFF9b"} "$$":[{"#name":"text" "_":"Dendritic cells HLA"} {"#name":"keyword" "$":{"id":"pc_m3nbRdSzln"} "$$":[{"#name":"text" "_":"Human leukocyte antigen ISCOMs"} {"#name":"keyword" "$":{"id":"pc_FfsE15lbnE"} "$$":[{"#name":"text" "_":"Immunostimulatory complexes MHC"} {"#name":"keyword" "$":{"id":"pc_eiglvbvOr6"} "$$":[{"#name":"text" "_":"Major histocompatibility complex |
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