| 硫酸锌对离体血管平滑肌的作用 |
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| 引用本文： | 马欣,李孝光. 硫酸锌对离体血管平滑肌的作用[J]. 药学学报, 1989, 24(10): 786-788 |
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| 作者姓名： | 马欣 李孝光 |
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| 作者单位： | 西安医科大学电生理研究室，西安医科大学电生理研究室 西安 710061，西安 710061 |
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| 摘 要： | 硫酸锌是体内一种重要的微量元素,它使离体动物心脏动作电位振幅降低,有效不应期延长,并能显著降低家兔窦房结自律性。本文采用离体豚鼠胸主动脉条和犬门静脉环标本,观察硫酸锌对KCl,CaCl_2和去甲肾上腺素(NE)诱发血管平滑肌收缩的影响。进一步探讨硫酸锌与Ca~(2 )的作用关系。
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| 关 键 词： | 硫酸锌 钙通道阻滞剂 |
| 收稿时间： | 1988-10-27 |
EFFECTS OF ZINC SULFATE ON ISOLATED VASCULAR SMOOTH MUSCLES |
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| X Ma and XG Li. EFFECTS OF ZINC SULFATE ON ISOLATED VASCULAR SMOOTH MUSCLES[J]. Acta pharmaceutica Sinica, 1989, 24(10): 786-788 |
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| Authors: | X Ma and XG Li |
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| Abstract: | ZnSO4 was found to inhibit the contractions of isolated guinea pig aortic preparations induced by KCl, CaCl2 and noradrenaline (NE). ZnSO4 (0.01-0.1 mmol/L) shifted the dose-response curves for KCl, CaCl2 and NE to the right, and depressed their maximal responses with PD2' values of 3.21, 3.07 and 2.91 respectively. ZnSO4 (0.1 mmol/L) significantly antagonized KCl, CaCl2 and NE-induced contraction responses in isolated dog portal vein preparations. These results suggest that the ZnSO4 induced relaxation of vascular smooth muscle might result from its antagonistic effect on transmembrane Ca2+ channels. |
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| Keywords: | Zinc sulfate Calcium channel blockers |
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