| 三磷酸腺苷脂质体的研究 |
| |
| 引用本文： | 徐国兴,谢星辉.三磷酸腺苷脂质体的研究[J].药学学报,1989,24(2):133-138. |
| |
| 作者姓名： | 徐国兴 谢星辉 |
| |
| 作者单位： | 国家医药管理局上海医药工业研究院，国家医药管理局上海医药工业研究院 上海 200040 无锡华瑞制药有限公司，上海 200040 |
| |
| 摘 要： | 本文就提高脂质体的药物包裹率，对质备方法进行了研究，提出了新的制备方法---改良乳化法（IEV），是ATP脂质体的药物包过率达到38.9%,超过文献方法，此法在国内外尚未见报道。选用草果滤技术分离未包裹的药物，用辐射灭菌法达到灭菌。这些方法对脂质体的 工业化生产有潜在的实用价值。
|
| 关 键 词： | 靶向给药系统 脂质体 乳化法 三磷酸腺苷 |
| 收稿时间： | 1987-12-28 |
STUDIES ON THE PREPARATION OF ADENOSINE TRIPHOSPHATE (ATP) LIPOSOMES |
| |
| GX Xu end XH Xie.STUDIES ON THE PREPARATION OF ADENOSINE TRIPHOSPHATE (ATP) LIPOSOMES[J].Acta Pharmaceutica Sinica,1989,24(2):133-138. |
| |
| Authors: | GX Xu end XH Xie |
| |
| Abstract: | In this paper, a method--improved emulsification vesicles (IEV) was proposed for the preparation of adenosine triphosphate (ATP) liposome. The ATP entrapment ratio reached 38.9% (w/w), which was much greater than that reported in the literature. Thus, IEV is an excellent method which has never been presented. Together with ultrafiltration for removing unentrapped drugs and radiation sterilization, these methods are most meaningful for the production of liposomes in large scale. |
| |
| Keywords: | Targeting drug delivery systems Liposomes Emulsification vesicles Adenosine triphosphate |
| 本文献已被 CNKI 维普 等数据库收录！ |
| 点击此处可从《药学学报》浏览原始摘要信息 |
| 点击此处可从《药学学报》下载免费的PDF全文 |
