| 二氢卟吩F甲醚的合成及其光敏化力和肿瘤光生物活性 |
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| 引用本文： | 姚建忠,陈文晖,贺祥,沈卫镝,刘建飞,周有骏,许德余.二氢卟吩F甲醚的合成及其光敏化力和肿瘤光生物活性[J].药学学报,2000,35(1):63-66. |
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| 作者姓名： | 姚建忠 陈文晖 贺祥 沈卫镝 刘建飞 周有骏 许德余 |
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| 作者单位： | 第二军医大学药学院,上海,200433 |
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| 基金项目： | 国家自然科学基金!39522003 |
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| 摘 要： | 光动力疗法（ｐｈｏｔｏｄｙｎａｍｉｃｔｈｅｒａｐｙ，ＰＤＴ）始于７０年代，现已发展成为新的肿瘤法定疗法。其治疗基础为：当一定波长的光辐照浓集光敏剂的肿瘤组织时，由敏化剂诱发光动力效应，导致肿瘤组织坏死而达到治疗目的［１］。目前，国内外临床应用的光敏剂如血卟啉衍生物（ｈｅｍａｔｏｐｏｒｐｈｙｒｉｎｄｅｒｉｖａｔｉｖｅ，ＨｐＤ）、光敏素ＩＩ（ｐｈｏｔｏｆｒｉｎＩＩ）和癌光啉（ＰＳＤ００７）等均为组成不定的复杂卟啉混合物，它们在红光区（λ＞６００ｎｍ）的吸收系数小而导致光动力反应深度不能满足浸润较深…
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| 关 键 词： | 蚕沙 二氢卟吩f甲醚 合成 肿瘤 光动力治疗 光敏剂 |
| 收稿时间： | 1999-06-15 |
| 修稿时间： | : |
SYNTHESIS AND PHOTOSENSITIZING ABILITIES AS WELL AS TUMOR-PHOTOBIOLOGICAL ACTIVITIES OF CHLORIN F METHYL ETHER |
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| Yao Jianzhong,Chen Weihui,He Xiang,Shen Weidi,Liu Jianfei,Zhou Youjun,Xu Deyu.SYNTHESIS AND PHOTOSENSITIZING ABILITIES AS WELL AS TUMOR-PHOTOBIOLOGICAL ACTIVITIES OF CHLORIN F METHYL ETHER[J].Acta Pharmaceutica Sinica,2000,35(1):63-66. |
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| Authors: | Yao Jianzhong Chen Weihui He Xiang Shen Weidi Liu Jianfei Zhou Youjun Xu Deyu |
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| Institution: | Yao Jianzhong, Chen Weihui, He
Xiang, Shen Weidi, Liu Jianfei, Zhou Youjun and Xu Deyu
(College of Pharmacy,Second Military Medical University,Shanghai 200433) |
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| Abstract: | AIM: To search for new photosensitizers for photodynamic therapy (PDT) of cancer. METHODS: Chlorin f methyl ether (1) is synthesized via addition and nucleophilic substitution reaction of 2 vinyl of chlorin f (3) which was prepared through acidic and alkaline oxidative degradation using silkworm excrement crude chlorophyll extracts as starting material. RESULTS: Compounds 1 and 2 are new compounds. Preliminary sensitizing effects on photooxidation of NADPH in D 2O and photodynamic effects for transplanted sarcoma S 180 in mice of compound 1 were shown to be stronger than those of hematoporphyrin derivative (HpD) and compound 3. CONCLUSION: It is suggested that compound 1 is possible to be developed as a new photosensitizer for PDT of cancer. |
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| Keywords: | silkworm excrement chlorin f methyl ether synthesis tumor photodynamic therapy photosensitizer |
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