蒙药紫花高乌头根中新二萜生物碱的分离和鉴定

目的:对蒙药紫花高乌头( Aconitum excelsum Reichb)根的化学成分进行分离鉴定。方法:用硅胶柱色谱进行分离,经IR,MS,¹HNMR,¹³CNMR和DEPT 等光谱鉴定化合物的结构。结果:从紫花高乌头根中得到9 个化合物,经光谱鉴定化合物分别是delsoline(II) ,6-demethyldelsodine(III),denudatine(IV),6-methylumbrofine(V) ,8-methyl-10-hydroxyllycoctonine(VI) ,gigactonine(VII) ,8-methyllycoctonine(VIII) ,lycoctonine(IX) 和puberaconitine(X) 。结论:化合物III,V,VI和VIII是新二萜生物碱,其余是已知二萜生物碱,这些化合物在本植物中为首次得到。

ISOLATION AND IDENTIFICATION OF NEW DITERPENOID ALKALOIDS FROM ROOT OF ACONITUM EXCELSUM REICHB

AIM: To isolate and identify the chemical constituents of the roots of Aconitum excelsum Reichb.METHODS: The chemical constituents were isolated by silica gel column chromatography and nine compounds were obtained. Their structures were elucidated by IR,MS,¹HNMR,¹³CNMR and DEPT. RESULTS: Nine compounds have been identified as delsoline(II),6 demethyldelsoline(III),denudatine(IV),6 methylumbrofine(V),8- methyl-10-hydroxyllycoctonine(VI),gigactonine(VII),8- methyllycoctonine(VIII),lycoctonine(IX) and puberaconitine(X) respectively. CONCLUSION: Compounds III,V,VI and VIII were new diterpenoid alkaloids, and the others were known compounds. These compounds were isolated from this plant for the first time。