| 丹酚酸对缺血性心脏病的作用及作用机制研究进展 |
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| 引用本文： | 阿瓦古丽·达吾提,方莲花,杜冠华.丹酚酸对缺血性心脏病的作用及作用机制研究进展[J].药学学报,2021(2):368-373. |
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| 作者姓名： | 阿瓦古丽·达吾提 方莲花 杜冠华 |
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| 作者单位： | 中国医学科学院、北京协和医学院药物研究所 |
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| 基金项目： | 国家自然科学基金资助项目(81773935);中国医学科学院医学与健康科技创新工程项目(2017-I2M-1-010,2016-I2M-3-007);国家科技重大专项(2018ZX09711001-010,2017ZX09101001)。 |
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| 摘 要： | 丹酚酸为唇形科植物丹参的最主要的水溶性活性成分,具有多种药理作用,被广泛应用于防治心血管疾病。本文通过查阅国内外最新研究文献,对丹酚酸防治缺血性心脏病的作用及作用机制进行综述,并介绍了丹酚酸A和丹酚酸B等丹参的主要水溶性成分通过保护血管内皮、舒张冠状动脉、促进血管再生、抗血小板聚集、抑制炎性反应、抗细胞凋亡和清除自由基等多角度防治缺血性心脏病的作用机制,为进一步研究丹酚酸对缺血性心脏病的作用及药物研发提供理论依据。
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| 关 键 词： | 丹参 水溶性成分 丹酚酸A 丹酚酸B 缺血性心脏病 |
Research advances on the protective effects and mechanism of salvianolic acids against ischemic heart disease |
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| DAWUTI Awaguli,FANG Lian-hua,DU Guan-hua.Research advances on the protective effects and mechanism of salvianolic acids against ischemic heart disease[J].Acta Pharmaceutica Sinica,2021(2):368-373. |
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| Authors: | DAWUTI Awaguli FANG Lian-hua DU Guan-hua |
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| Institution: | (Beijing Key Laboratory of Drug Targets Identification and Drug Screening,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050,China) |
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| Abstract: | Salvianolic acids are the main water-soluble active compounds of Salvia miltiorrhiza and have been widely used for the treatment of cardiovascular diseases.Based on the latest studies in China and abroad,we summarize the pharmacological effects and mechanism of salvianolic acids on ischemic heart disease by describing how salvianolic acid A and salvianolic acid B protect the vascular endothelium,relax coronary arteries,promote angiogenesis and anti-platelet aggregation,inhibit the inflammatory response,anti-cell apoptosis,and scavenge free radicals.This review provides a theoretical basis for further research on the effects of salvianolic acids on ischemic heart disease and their potential for drug development. |
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| Keywords: | Salvia miltiorrhiza water-soluble component salvianolic acid A salvianolic acid B ischemic heart disease |
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