大黄橐吾的化学成分

大黄橐吾(Ligularia duciformis)为菊科橐吾属植物，据报道有治疗支气管炎、咳嗽等功效。为寻找其生物活性成分，对其根和根茎的85%乙醇提取物进行了溶剂萃取和硅胶、Sephadex LH-20柱色谱分离。从乙酸乙酯部位得到6个化合物，经理化性质和波谱数据分析，鉴定为咖啡酸-(3-甲氧基-4-羟基)苯丙酯(I)，6β,8β-双羟基雅槛蓝-7(11)-烯-12,8α-内酯(II)，6β,8α-双羟基雅槛蓝-7(11)-烯-12,8β-内酯(III)，6β-羟基雅槛蓝-7(11)-烯-12,8α内酯(IV)，豆甾醇(V)，胡萝卜苷(VI)。化合物I为新化合物，化合物II～V为首次从该植物中分得。化合物的止咳作用正在评价中。

Chemical constituents of Ligularia duciformis

Ligularia duciformis is a plant of the Ligularia genus (Compositae) which has been reported to have therapeutic effects of treating diseases such as bronchitis and coughing. In order to find out the bioactive components, the 85% ethanol extract of the root and rhizome of L. duciformis was treated by solvents extraction and column chromatography on silica gel and Sephadex LH-20. Six compounds were obtained from the ethyl acetate fraction and identified as 3-methoxy-4-hydroxyphenylpropyl caffeate (I), 6beta, 8beta-dihydroxyeremophil-7 (11)-en-12, 8alpha-olide (II), 6beta, 8alpha-dihydroxyeremophil-7 (11)-en-12, 8beta-olide (III), 6beta-hydroxyeremophil-7 (11)-en-12, 8alpha-olide (IV), stigmasterol (V) and beta-daucosterol (VI) by analysis of their physic-chemical constants and spectral data. Compound I is a new compound and compounds II - V were isolated from L. duciformis for the first time. The antitussive effect of the compounds is under evaluation.