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紫杉醇生物合成的研究进展
引用本文:孔建强,王伟,朱平,程克棣.紫杉醇生物合成的研究进展[J].药学学报,2007,42(4):358-365.
作者姓名:孔建强  王伟  朱平  程克棣
作者单位:中国医学科学院、中国协和医科大学,药物研究所,北京,100050
摘    要:紫杉醇是一种抗癌新药。紫杉醇及其衍生物还具有防治移植动脉硬化、抗瘢痕形成和抗血管生成等功能。目前,人们获得紫杉醇的方法主要有以下几种:直接从红豆杉中提取;化学全合成;化学半合成;细胞培养;内生真菌提取培养及代谢工程生产紫杉醇。已从红豆杉中克隆出了至少14个和紫杉醇生物合成相关的基因并进行了功能鉴定。紫杉醇生物合成途径的阐明带动了紫杉醇前体组合表达系统的研究。

关 键 词:紫杉醇  生物合成途径  组合表达
文章编号:0513-4870(2007)04-0358-08
收稿时间:2006-09-14
修稿时间:2006-09-14

Recent advances in the biosynthesis of taxol
KONG Jian-qiang,WANG Wei,ZHU Ping,CHENG Ke-di.Recent advances in the biosynthesis of taxol[J].Acta Pharmaceutica Sinica,2007,42(4):358-365.
Authors:KONG Jian-qiang  WANG Wei  ZHU Ping  CHENG Ke-di
Institution:Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
Abstract:Taxol is one of the most potent chemotherapeutic agents known,showing excellent activity against a range of cancers.In addition to anticancer,taxol has the effect of preventing graft arterioscleriosis,antiscaring formation and inhibiting angiogenesis.There are five possible routes to industrialize taxol production: isolation from the bark of the yew species,total synthesis,semisynthesis,tissue or cell culture,endophytic fungal fermentation and metabolism engineering.There are at least 14 genes related to the taxol biosynthesis had been cloned from yews and functionally expressed in different hosts.The combinational expression system of taxol makes progress as the clarification of biosynthetic pathway of taxol.
Keywords:taxol  biosynthetic pathway  combinational expression
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