醋氨己酸锌在大鼠的药代动力学

测定了醋氨已酸锌(ZAC)在大鼠体内的药代动力学。结果表明:大鼠poZAC吸收迅速,给药后1.5h即可达峰,其后稍快下降。3个剂量组的吸收峰时及半衰期基本一致,T_1/2约在1.5h,峰浓度、AUC及CL/F呈剂量依赖关系。ZAC在大鼠的药代动力学模型为一室模型。组织分布的实验结果表明:服药2h后药物可广泛分布于各组织中,主要集中在胃、肠;肾、肝、血浆及肺次之;心、脾、脑较低;肌肉、子宫未检出。6h后胃中含锌量稍降,肺中含量变化不大,其它组织的药物浓度普遍明显下降,表明该药在组织中不易蓄积。ZACpo后主要经粪排出,尿及胆汁仅排出少量药物。

PHARMACOKINETICS OF ZINC ACEXAMATE(ZAC)IN RATS

Zinc acexamate(ZAC)is a new antiulcer drug.This paper reports the pharma-cokinetics of ZAC in rats after single oral administration.The concentrations in biological sampleswere detected by spectrophotometry.This study shows that the concentration-time curve of ZAC inblood conformed to a single-compartment open model after 250,500 and 750 ng·kg^-1 ig.ZACabsorption was fast and the peak plasma level appeared in 1.5h.The C_max,AUC and CL/F wereshown to be dose dependent.Two hours after oral administration of ZAC to nomal rats,the highestlevel of ZAC was present in the gastrointestinal tract,while appreciable ZAC was present in thekidney,liver,plasma and lung.The level of ZAC in heart,spleen and brain Was lower,no drug wasdetected in muscles and uterus.Six hours after oral administration,the drug concentration in varioustissues decreased rapidly,but that of the gastrointestinal decreased very slowly.Feces excretion was animportent route of excretion.ZAC excretion was about 11.7% of the administered dosage in feceswithin 48 h period,and the excreted amount from urine and bile was very small.