| 几类重要的海洋抗肿瘤药物研究进展 |
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| 引用本文： | 张建业,符立梧.几类重要的海洋抗肿瘤药物研究进展[J].药学学报,2008,43(5):435-442. |
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| 作者姓名： | 张建业 符立梧 |
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| 作者单位： | 中山大学,肿瘤防治中心,华南肿瘤学国家重点实验室,广东,广州,510060 |
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| 基金项目： | 国家高技术研究发展计划(863计划) |
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| 摘 要： | 目前对海洋抗肿瘤药物的研究已经成为全世界普遍关注的热点。近年来，苔藓抑素、ecteinascidin-743、海兔毒肽、膜海鞘素、psammaplin、软海绵素B等六类化合物的研究取得了较大进展。本文综述这几类海洋抗肿瘤药物及其衍生物的研究进展，并探讨海洋抗肿瘤药物发展的趋势。
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| 关 键 词： | 海洋天然产物 抗肿瘤药物 研究进展 |
| 文章编号： | 0513-4870(2008)05-0435-08 |
| 收稿时间： | 2007-09-10 |
| 修稿时间： | 2007年9月10日 |
Advance of several types of important marine antitumor drugs |
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| ZHANG Jian-ye,FU Li-wu.Advance of several types of important marine antitumor drugs[J].Acta Pharmaceutica Sinica,2008,43(5):435-442. |
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| Authors: | ZHANG Jian-ye FU Li-wu |
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| Institution: | State Key laboratory of Oncology in South China, Cancer Center, Sun Yat-sen University, Guangzhou, 510060, China. |
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| Abstract: | Marine antitumor drugs have been the research focus in the world. Recently, advancement has been made in the investigation of six types of compounds including bryostatin-1, ecteinascidin-743, dolastatin, didemnin B, psammaplin and halichondrin B. In this review, we summarized the recent research progress of the above mentioned marine antitumor drugs and their derivatives. Also, the development tendency of marine antitumor drugs was discussed. |
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| Keywords: | antitumor drug progress marine natural product |
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