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大叶香茶菜抗肿瘤成分大叶庚的研究(Ⅱ)
引用本文:程培元,许美娟,林永乐,石金城.大叶香茶菜抗肿瘤成分大叶庚的研究(Ⅱ)[J].药学学报,1982,17(12):917-921.
作者姓名:程培元  许美娟  林永乐  石金城
作者单位:南京药物研究所 (程培元,许美娟,林永乐),南京药物研究所(石金城)
摘    要:鉴定了从大叶香茶菜Rabdosia macrophylla中分得的另外四种成分。三种为已知成分乌苏酸,香茶菜甲素(AmethystoidinA)及Enmenol。另一大叶庚为新的B-seco-ent-kaurene二萜,命名为RabdophyllinG,能延长荷艾氏腹永癌小鼠的生命并能抑制体外肝癌细胞的生长。

关 键 词:大叶香茶菜  大叶香茶菜庚  香茶菜甲素  Enmenol  乌苏酸
收稿时间:1981-08-17

THE STRUCTURE OF RABDOPHYLLIN G,AN ANTITUMOR CONSTITUENT OF RABDOSIA MACROPHYLLA (Ⅱ)
CHENG Pei-yuan,XU Mei-juan,LIN Yong-le and SHI Jin-cheng.THE STRUCTURE OF RABDOPHYLLIN G,AN ANTITUMOR CONSTITUENT OF RABDOSIA MACROPHYLLA (Ⅱ)[J].Acta Pharmaceutica Sinica,1982,17(12):917-921.
Authors:CHENG Pei-yuan  XU Mei-juan  LIN Yong-le and SHI Jin-cheng
Institution:Nanjing Institute of Materia Medica
Abstract:The identification of four components of Rabdosia macrophylla was accomplished, three of them were shown to be identical with the known Amethystoidin A, ursolic acid and Enmenol. The 4th. is a new B-seco-ent-kaurene diterpenoid, to which the name Rabdophyllin G is suggested. Spectroscopic investigation and chemical conversion into dihydroisodonal (Ⅲ) and dihydroisodonal derivative (Ⅳ) established the structure of Rabdophyllin G. It exhibited significant inhibitory action against Ehrlich ascites carcinoma in mice.
Keywords:Rabdosia macrophylla  Rabdophyllin G  Amethystoidin A  Enmenol  Ursolic acid  
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