| 肿节风倍半萜类化学成分研究 |
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| 作者姓名： | Li X Zhang YF Yang L Feng Y Liu YM Zeng X |
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| 作者单位： | 广州中医药大学第二附属医院;浙江大学药学院; |
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| 基金项目： | 广东省中医药管理局课题(20111208) |
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| 摘 要： | 为了研究肿节风全草中倍半萜类化学成分,利用硅胶柱色谱、凝胶柱色谱、ODS柱色谱及制备液相色谱等分离技术从肿节风70%乙醇提取物的正丁醇和乙酸乙酯萃取部分分离得到4个倍半萜内酯类成分,根据化合物的光谱数据分别鉴定为4α-hydroxy-5αH-lindan-8(9)-en-8,12-olide(1)、chloranthalactone E(2)、8β,9α-dihydroxylindan-(5),7(1)-ieb-8α,12-olide(3)和chloranoside A(4)。其中化合物1为新化合物。
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| 关 键 词： | 肿节风 化学成分 倍半萜 |
Sesquiterpenoids from the whole plant of Sarcandra glabra |
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| Li X,Zhang YF,Yang L,Feng Y,Liu YM,Zeng X.Sesquiterpenoids from the whole plant of Sarcandra glabra[J].Acta Pharmaceutica Sinica,2011,46(11):1349-1351. |
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| Authors: | Li Xiong Zhang Yu-feng Yang Liu Feng Yi Liu Yi-ming Zeng Xing |
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| Institution: | LI Xiong1,ZHANG Yu-feng2,YANG Liu1,FENG Yi1,LIU Yi-ming1,ZENG Xing1(1.Second Affiliated Hospital,Guangzhou University of Traditional Chinese Medicine,Guangzhou 510120,China,2.College of Pharmaceutical Sciences,Zhejiang University,Hangzhou 310058,China) |
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| Abstract: | To study the sesquiterpenoid constituents in the whole plant of Sarcandra glabra, silical column chromatography, Sephadex LH-20, reverse phase ODS column chromatography and preparative HPLC were used to isolate 70% EtOH extract of Sarcandra glabra. The structures were elucidated based on spectroscopic data (HR-ESI-MS, 1H NMR, 13C NMR, HSQC, HMBC and NOESY). Four sesquiterpenoids were obtained and identified as 4alpha-hydroxy-5alphaH-lindan-8 (9)-en-8, 12-olide (1), chloranthalactone E (2), 8beta, 9alpha-dihydroxylindan-(5), 7 (1)-ieb-8alpha, 12-olide (3) and chloranoside A (4), respectively. Compound 1 is a new sesquiterpene lacone. |
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| Keywords: | Sarcandra glabra chemical constituent sesquiterpenoids |
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