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虫胶的理化性质与肠溶性能关系及其改善方法
引用本文:翁帼英,郭建兰,陈思义.虫胶的理化性质与肠溶性能关系及其改善方法[J].药学学报,1982,17(5):395-399.
作者姓名:翁帼英  郭建兰  陈思义
作者单位:南京药物研究所 (翁帼英,郭建兰),南京药物研究所(陈思义)
摘    要:市售虫胶种类繁多,以往仅认为药用虫胶应为无砷、漂白、透明。在实际应用中常发现肠溶性能不稳定,包衣工艺过程不易控制,致使不同厂的产品或不同批号的肠溶性能各有差异。Wagner报道氨制虫胶片久置崩解时间延长。桧桓认为虫胶肠溶片的片心影响它的崩解时间,而虫胶衣本身是稳定的。Hick则认为虫胶久置后产生聚合,表现为冷醇不溶物增加,碘价降低,诸说不一。本文对虫胶的理化性质与肠溶性能关系及附加剂对改善虫胶肠溶性能进行了探讨。

关 键 词:虫胶  碘价  软皂  肠溶包衣片
收稿时间:1980-12-23

THE RELATIONSHIP BETWEEN PHYSICOCHEMICAL PROPERTIES AND ENTERIC DISSOLUTION OF SHELLAC AND ITS MODIFICATION
WENG Guo-ying,GUO Jian-lan and CHEN Si-yi.THE RELATIONSHIP BETWEEN PHYSICOCHEMICAL PROPERTIES AND ENTERIC DISSOLUTION OF SHELLAC AND ITS MODIFICATION[J].Acta Pharmaceutica Sinica,1982,17(5):395-399.
Authors:WENG Guo-ying  GUO Jian-lan and CHEN Si-yi
Institution:Nanjing Institute of Meteria Medica
Abstract:Six commercial shellac samples were used for the preparation of enteric coating material. Its iodine value, saponification value, acid value and alcohol-insoluble substance have been determined. The results indicated the relation between enteric disintegration properties of shellac and its physical-chemical data. The material with iodine value of 8~10 and alcohol-insoluble substance below 10% were suitable for enteric coating. Soft soap can modify enteric disintegration properties of shellac. Significant differences were found between the modified and non-modified shellac coating formulation. Shellac incorporated with soft soap can decrease the disintegration time of shellac enteric coating in pH6.8~7.5 medium and increase its stability.
Keywords:Shellac  Iodine value  Soft soap Enteric coating tablet
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