| 6-(αα-二苯基乙酰哌嗪基苯基)-4,5-二氢-5-甲基-3(2H)-哒嗪酮对兔血小板聚集及TXB2,cAMP的影响 |
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| 引用本文： | 曾国钱,王雪松,孙笃新,林爱友,嵇杨,褚建雄,芮耀诚.6-(αα-二苯基乙酰哌嗪基苯基)-4,5-二氢-5-甲基-3(2H)-哒嗪酮对兔血小板聚集及TXB2,cAMP的影响[J].药学学报,1993,28(4):256-259. |
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| 作者姓名： | 曾国钱 王雪松 孙笃新 林爱友 嵇杨 褚建雄 芮耀诚 |
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| 作者单位： | 第二军医大学药学院药理教研室,上海200433 |
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| 摘 要： | 6-(αα-二苯基乙酰哌嗪基苯基)-4,5-二氢-5-甲基-3(2H)-哒嗪酮(简称DMDP)是我院新合成的哒嗪酮的衍生物。DMDP可以显著抑制由花生四烯酸(AA(?),ADP和血小板活化因子(PAF)诱导的免血小板聚集,其IC50分别为1.12±0.1.4.19±0.5和2.97±0.1μmol/L。实验还表明DMDP在1～500 μmol/L浓度范围内呈剂量依赖性地抑制兔血小板内血栓素B2含量,但升高兔血小板内环腺苷酸水平,这可能是其抑制血小板聚集的作用机理之一。
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| 关 键 词： | 6-(αα-二苯基乙酰哌嗪基苯基)-4 5-二氢-5-甲基-3(2H)-哒嗪酮 血栓素B2 环腺苷酸 血小板聚集 |
| 收稿时间： | 1992-08-11 |
EFFECTS OF 6-(αα-DIPHENYLACETYLPIPERAZINYL) PHENYL-5-METHYL-4, 5-DIHYDRO- 3 (2H) -PYRIDAZINONE ON RABBIT PLATELET AGGREGATION AND TXB2, cAMP PRODUCTION |
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| GQ Zeng,XS Wang,DX Sun,AY Lin,Y Ji,JX Chu and YC Rui.EFFECTS OF 6-(αα-DIPHENYLACETYLPIPERAZINYL) PHENYL-5-METHYL-4, 5-DIHYDRO- 3 (2H) -PYRIDAZINONE ON RABBIT PLATELET AGGREGATION AND TXB2, cAMP PRODUCTION[J].Acta Pharmaceutica Sinica,1993,28(4):256-259. |
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| Authors: | GQ Zeng XS Wang DX Sun AY Lin Y Ji JX Chu and YC Rui |
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| Abstract: | 6-(αα-diphenylacetylpiperazinyl) phenyl- 5-methyl- 4,5-dihydro- 3 (2H)-pyridazinone (DMDP) is a new synthetic pyridazinone derivative. This compound was shown to inhibit AA, ADP and PAF-induced rabbit platclet aggregation, and its IC50s were found to be 1.12±0. 1, 4. 19±0. 5 and 2. 97±0. 1 μmol/L, respectively. At the concentration range of 1～500 μmol/L, the compound was found to depress TXB2 content and to increase cAMP levels in washed rabbit platelets in a dose--dependent manner. These might be the mechanisms of the compound on the inhibition of rabbit olatelets. |
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| Keywords: | Thromboxane B2 (TXB2) cAMP Platelet aggregation 6-(αα-diphenylacetylpiperazinyl) phenyl- 5- methyl- 4 5- dihydro- 3 (2H)-pyridazinone |
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