| 高效液相色谱法测定血清中依普拉芬浓度及在人体的药代动力学研究 |
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| 引用本文： | 马晓红,许逸,刘天培.高效液相色谱法测定血清中依普拉芬浓度及在人体的药代动力学研究[J].药学学报,1997,32(6):470-472. |
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| 作者姓名： | 马晓红 许逸 刘天培 |
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| 作者单位： | 南京医科大学基础医学院药理教研室 |
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| 摘 要： | 高效液相色谱法测定血清中依普拉芬浓度及在人体的药代动力学研究马晓红许逸刘天培（南京医科大学基础医学院药理教研室，南京２１００２９）依普拉芬（ｉｐｒｉｆｌａｖｏｎｅ，７异丙氧基异黄酮）为一合成的异黄酮衍生物，是新型治疗骨质疏松药物。它主要通过抑制骨吸...
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| 关 键 词： | 依普拉芬 高效液相色谱 药代动力学 生物利用度 |
| 收稿时间： | 1996-11-10 |
HIGH PERFORMANCE LIQUID CHROMATOGRAPHIC METHOD FOR THE DETERMINATION OF IPRIFLAVONE IN SERUM AND ITS PHARMACOKINETIC STUDY IN HEALTHY VOLUNTEERS |
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| XH Ma,Y Xu and TP Liu.HIGH PERFORMANCE LIQUID CHROMATOGRAPHIC METHOD FOR THE DETERMINATION OF IPRIFLAVONE IN SERUM AND ITS PHARMACOKINETIC STUDY IN HEALTHY VOLUNTEERS[J].Acta Pharmaceutica Sinica,1997,32(6):470-472. |
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| Authors: | XH Ma Y Xu and TP Liu |
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| Institution: | Department of Pharmacology, Nanjing Medical University, Nanjing 210029. |
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| Abstract: | A sensitive and rapid high performance liquid chromatographic method has been developed for the determination of ipriflavone in human serum. The average recovery of ipriflavone was 85% with relative standard deviation of 3.8%-5.4%. The calibration curve was linear in the range from 8 ng.ml-1 to 400 ng.ml-1 with gamma = 0.9981. The detection limit of the method was 3 ng.ml-1 (S/N > or = 3). The serum drug concentration-time curve exhibited a 2-compartment model and the mean T1/2 beta was 12.00 +/- 1.89 h (for ipriflavone made in Japan) and 9.05 +/- 0.80 h (for ipriflavone made in China). The AUC0-->infinity of the two kinds of ipriflavone were 804.99 ng.h.ml-1 and 807.40 ng.h.ml-1, respectively. The relative bioavailability of ipriflavone made in China vs that made in Japan was 1.003. |
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| Keywords: | Ipriflvaone HPLC Pharmacokinetics Bioavailabitity |
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