利血平与优降宁对动物痛阈和吗啡镇痛作用影响因素探讨

采用三种测痛方法,观察了利血平、优降宁对小鼠、大鼠正常痛阈和吗啡镇痛作用的影响,结果表明:ip利血平2 mg/kg,优降宁100 mg/kg均能明显抑制小鼠扭体反应;ip利血平1 mg/kg能明显提高小鼠热板反应时间,但ip优降宁75 mg/kg无明显影响;ip利血平6 mg/kg,优降宁75 mg/kg对大鼠甩尾反应时间均无明显影响;利血平(小鼠0.5～1.0 mg/kg,大鼠2 mg/kg ip)能明显对抗吗啡镇痛作用;优降宁(小鼠35 mg/kg,大鼠50 mg/kg ip)能明显增强吗啡镇痛作用,并能“逆转”利血平对抗吗啡镇痛作用。其“逆转”作用的强弱取决于利血平、优降宁给药的先后次序。

STUDIES ON FACTORS AFFECTING. THE ACTIONS OF RESERPINE AND PARGYLINE ON NORMAL PAIN THRESHOLD IN MICE AND RATS, AND ON THE MODIFICATION OF MORPHINE ANALGESIA

Mouse writhing response, hot-plate test and rat tail-flick tests were used to study the influence of reserpine and pargyline on the normal pain threshold in mice and rats and on the analgesia of morphine. The results are as follows: The writhing response in mice was inhibited after ip of reserpine at a dose of 2 mg/kg, or pargyline 100 mg/kg. The paw lick latency in mouse hot-plate test was prolonged following reserpine (1 mg/kg, ip) but not influenced, by pargyline. The tail-flick latency in rats was affected by neither reserpine (6 mg/kg, ip) nor pargyline (75 mg/kg,ip). The analgesic effect of morphine was antagonized by reserpine (0.5 mg/kg and 1 mg/kg ip in mice or 2 mg/kg ip in rats), and potentiated by pargyline (35 mg/kg ip in mice, or 50 mg/kg ip in rats). The antagonistic effect of reserpine against morphine was reversed by pargyline, and this effect was found to be dependent on the sequence of the administration of reserpine and pargyline. The analgesic effect of morphine was potentiated by administering pargyline and reserpine at the same time or by giving pargyline half an hour before reserpine. But the analgesic effect of morphine was decreased when reserpine was given before pargyline.