| 山莨菪碱和蝙蝠葛碱对白三烯和PAF诱导的牛脑前动脉平滑肌细胞DNA合成的影响(英文) |
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| 引用本文： | 曾国钱,鞠佃文,孙笃新,芮耀诚.山莨菪碱和蝙蝠葛碱对白三烯和PAF诱导的牛脑前动脉平滑肌细胞DNA合成的影响(英文)[J].药学学报,1992(8). |
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| 作者姓名： | 曾国钱 鞠佃文 孙笃新 芮耀诚 |
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| 作者单位： | 第二军医大学药学院药理教研室，第二军医大学药学院药理教研室，第二军医大学药学院药理教研室，第二军医大学药学院药理教研室 上海 200433，上海 200433，上海 200433，上海 200433 |
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| 基金项目： | Project supported by the Chinese National Natural Science Foundation,No.3880742. |
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| 摘 要： | 白三烯和血小板活化因子在低于nmol浓度时就能刺激培养的牛脑前动脉平滑肌细胞的DNA合成,在10~(-7)mol/L时达最大刺激。LTB_4,LTD_4和PAF在10~(-7)mol/L时对上述细胞DNA合成的刺激率分别为32％,29％和77％。山莨菪碱和蝙蝠葛碱在10~(-7)～10~(-4)mol/L范围内呈剂量依赖性地抑制白三烯和血小板活化因子的上述作用。
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| 关 键 词： | 山莨菪碱 蝙蝠葛碱 脱氧核糖核酸 血管平滑肌 |
EFFECTS OF DAURICINE AND ANISODAMINE ON LTs AND PAF INDUCED DNA SYNTHESIS IN BOVINE ANTERIOR CEREBRAL ARTERIAL SMOOTH MUSCLE CELLS |
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| GQ Zeng,DW Ju,DX Sun,YC Rui.EFFECTS OF DAURICINE AND ANISODAMINE ON LTs AND PAF INDUCED DNA SYNTHESIS IN BOVINE ANTERIOR CEREBRAL ARTERIAL SMOOTH MUSCLE CELLS[J].Acta Pharmaceutica Sinica,1992(8). |
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| Authors: | GQ Zeng DW Ju DX Sun YC Rui |
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| Institution: | GQ Zeng,DW Ju,DX Sun,YC Rui Department of Pharmacology,School of Pharmacy,Second Military Medical University,Shanghai 200433 |
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| Abstract: | The effects of leukotrienes (LTs) and platelet activating factor (PAF)on DNA synthesis in bovine anterior cerebral arterial smooth muscle cells were studied. Theresults showed that LTB_4, LTD_4 and PAF were all stimulatory to the cells. The maximalrates of stimulation were 32%, 29% and 77%, respectively, for LTB_4, LTD_4 and PAF at10~(-7) mol/L. Both dauricine and anisodamine at concentrations of 10~(-7) to 10~(-4) mol/L ex-hibited strong inhibitory effects on LTs and PAF induced DNA synthesis. |
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| Keywords: | Dauricine Anisodamine DNA Vascular smooth muscle |
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