| 人红细胞膜脂三尖杉酯碱脂质体包裹率及稳定性的研究 |
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| 引用本文： | 杨秀芬,马玉芬,陈正秋,范启修.人红细胞膜脂三尖杉酯碱脂质体包裹率及稳定性的研究[J].药学学报,1989,24(12):957-960. |
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| 作者姓名： | 杨秀芬 马玉芬 陈正秋 范启修 |
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| 作者单位： | 中国医学科学院血液学研究所生化及分子生物学研究室，中国医学科学院血液学研究所生化及分子生物学研究室，中国医学科学院血液学研究所生化及分子生物学研究室，中国医学科学院血液学研究所生化及分子生物学研究室 天津 300020，天津 300020，天津 300020，天津 300020 |
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| 基金项目： | 本课题由卫生部青年科学基金 |
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| 摘 要： | 自Ryman等开始将脂质体作为药物载体研究以来已取得很大进展。但药物脂质体用于临床的报道甚少,原因之一是脂质体对药物的包裹率较低,稳定性也差。较大的脂质体进入体内后主要被网状内皮系统所吞噬,不能较多地到达靶区,而小单层脂质体则在肝脾的
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| 关 键 词： | 脂质体 三尖杉酯碱 包裹率 稳定性 |
| 收稿时间： | 1988-08-10 |
STUDY OF THE EFFICIENCY AND STABILITY OF HARRINGTONINE ENCAPSULATION IN WHOLE PHOSPHOLIPID VESICLE FROM HUMAN ERYTHROCYTE MEMBRANE |
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| XF Yang,YF Ma,ZQ Chen and QX Fan.STUDY OF THE EFFICIENCY AND STABILITY OF HARRINGTONINE ENCAPSULATION IN WHOLE PHOSPHOLIPID VESICLE FROM HUMAN ERYTHROCYTE MEMBRANE[J].Acta Pharmaceutica Sinica,1989,24(12):957-960. |
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| Authors: | XF Yang YF Ma ZQ Chen and QX Fan |
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| Abstract: | The whole phospholipid of human erythrocyte membrane was used to prepare small unilamellar vesicles (SUV) of harringtonine by reversed phase evaporation combined with sonication scattering method. The percentage of harringtonine encapsulation and its stability were also studied. The results showed that the concentration of phospholipid and its degree of oxidation were the main influencing factors. The percentage of harringtonine encapsulation under our experimental conditions reached 21.5%. Stability test showed that the rate of leakage of harringtonine from liposome was 7.3% when stored at 4 degrees C for two months. |
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| Keywords: | Liposome Harringtonine Encapsulation Stability |
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