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红花黄素对高血压大鼠的降压作用及对肾素-血管紧张素的影响
引用本文:刘发,魏苑,杨新中,李芳桂,胡坚,程瑞芬.红花黄素对高血压大鼠的降压作用及对肾素-血管紧张素的影响[J].药学学报,1992,27(10):785-787.
作者姓名:刘发  魏苑  杨新中  李芳桂  胡坚  程瑞芬
作者单位:新疆医学院药理教研室;*实验动物供应室,乌鲁木齐830054;**新疆药物研究所,乌鲁木齐830001
摘    要:Safflower yellow (SY) is a mixture of chalconoid compounds extracted from Carthamus tinctorius L. Ig SY 1~2 g·kg-1·d-1lowered the blood pressure of spontaneously hypertensiverats (SHR), for about 1.86~3.86 kPa. Five weeks after administration of SY, the plasma renin ac-tivity and angiotensin Ⅱ level diminished in the SHR experimental groups. These suggest that the de-crease of blood pressure is mediated by the renin-angiotensin system.

关 键 词:红花黄素  自发性高血压大鼠  放射免疫测定  肾素  血管紧张素П
收稿时间:1991-09-28

HYPOTENSIVE EFFECTS OF SAFFLOWER YELLOW IN SPONTANEOUSLY HYPERTENSIVE RATS AND INFLUENCE ON PLASMA RENIN ACTIVITY AND ANGIOTENSIN II LEVEL
F Liu,Y Wei,XZ Yang,FG Li,J Hu,RF Cheng.HYPOTENSIVE EFFECTS OF SAFFLOWER YELLOW IN SPONTANEOUSLY HYPERTENSIVE RATS AND INFLUENCE ON PLASMA RENIN ACTIVITY AND ANGIOTENSIN II LEVEL[J].Acta Pharmaceutica Sinica,1992,27(10):785-787.
Authors:F Liu  Y Wei  XZ Yang  FG Li  J Hu  RF Cheng
Institution:Department of Pharmacology, Xin jing Medical College, Urümuqi.
Abstract:Safflower yellow (SY) is a mixture of chalconoid compounds extracted from Carthamus tinctorius L. Ig SY 1-2 g.kg-1.d-1 lowered the blood pressure of spontaneously hypertensive rats (SHR), for about 1.86-3.86 kPa. Five weeks after administration of SY, the plasma renin activity and angiotensin II level diminished in the SHR experimental groups. These suggest that the decrease of blood pressure is mediated by the renin-angiotensin system.
Keywords:Spontaneously hypertensive rat  Renin  Angiotensin Ⅱ  Radiodioimmunoassay  Safflower yellow
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