| 光学纯羟基醚类化合物的合成和分离 |
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| 引用本文： | 高建华,文广伶,张其楷.光学纯羟基醚类化合物的合成和分离[J].药学学报,1987,22(9):708-710. |
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| 作者姓名： | 高建华 文广伶 张其楷 |
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| 作者单位： | 军事医学科学院药物毒物研究所 北京
(高建华，文广伶)，军事医学科学院药物毒物研究所 北京(张其楷) |
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| 摘 要： | dl-羟基醚类化合物3-奎宁环基-2’,2’,2’-苯基环戊基羟基乙基醚Ⅰ的抗胆碱作用已有报道。
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| 关 键 词： | 抗胆碱物 光学异构体 羟基醚衍生物 |
| 收稿时间： | 1986-12-23 |
THE SYNTHESIS AND SEPARATION OF OPTICALLY PURE HYDROXY ETHERS |
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| GAO Jian-Hua. WEN Guang-Ling and ZHANG Qi-Kai.THE SYNTHESIS AND SEPARATION OF OPTICALLY PURE HYDROXY ETHERS[J].Acta Pharmaceutica Sinica,1987,22(9):708-710. |
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| Authors: | GAO Jian-Hua WEN Guang-Ling and ZHANG Qi-Kai |
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| Institution: | Institute of Pharmacology and Toxicology. Academy of Military Medical Sciences. Beijing |
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| Abstract: | By using optically pure R and S 3-quinuclidinols. two pairs of diastereoisomers (R-1) and (R-2), (S-1) and (S-2) were synthesized. Each pair was further separated by preparative TLC. The mobile phase was chloroform-methanol-ammonia water (8:2:0.07). There is a marked distinction among their affinities for M-cholinergic receptor in rat hrain The work is still in progress. |
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| Keywords: | Anticholinergics: Optical isomers: Hydroxy ether derivatives |
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