| 赤芍的化学成分研究 |
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| 引用本文： | 段文娟,姜 艳,靳 鑫,覃耿垚,邱 峰.赤芍的化学成分研究[J].中国药物化学杂志,2009,19(1):55-58. |
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| 作者姓名： | 段文娟 姜 艳 靳 鑫 覃耿垚 邱 峰 |
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| 作者单位： | 1.沈阳药科大学 中药学院，辽宁 沈阳110016；2.辽宁成大方圆医药连锁有限公司，辽宁 大连 116021 |
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| 摘 要： | 目的 对中药赤芍(Paeonia albiflora)的化学成分进行研究。方法 采用硅胶柱色谱、Sephadex LH-20柱色谱、Pe-TLC、Pe-HPLC等方法进行分离纯化，并通过理化常数和波谱学数据分析鉴定其化学结构。结果 分离得到10个已知化合物，分别鉴定为evofolin B (1)、(1S, 2S, 4R)-trans-2-hydroxy-1, 8-cineole-β-D-glucopyranoside (2)、(2R, 3R)- 4-methoxyl-distylin (3)、1, 2, 3, 4, 6-五-没食子酰基葡萄糖 (4)、儿茶素(5)、苯甲酸 (6)、没食子酸 (7)、香草酸 (8)、没食子酸甲酯 (9)、没食子酸乙酯 (10)。结论 化合物1~3为首次从该属植物中分离得到。
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| 关 键 词： | 赤芍 化学成分 结构鉴定 乙醇提取物 |
| 收稿时间： | 2008-7-1 |
| 修稿时间： | 2008-10-30 |
Chemical constituents of Paeonia albiflora |
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| DUAN Wen-juan,JIANG Yan,JIN Xin,QIN Geng-yao,QIU Feng.Chemical constituents of Paeonia albiflora[J].Chinese Journal of Medicinal Chemistry,2009,19(1):55-58. |
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| Authors: | DUAN Wen-juan JIANG Yan JIN Xin QIN Geng-yao QIU Feng |
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| Institution: | 1. School of Traditional Chinese Materia Media, Shenyang Pharmaceutical University, Shenyang 110016,China；2. Liaoning Chengda Fangyuan Pharmaceutical Co.Ltd., Dalian 116021, China |
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| Abstract: | Aim To study the chemical constituents of Paeinia albiflora. Methods Ten compounds were isolated by chromatography on silica gel column, Sephadex LH-20, Pe-TLC, Pe-HPLC and identified on the basis of physico-chemical constant and spectral analysis. Results and conclusions Ten compounds were isolated and their structures were identified as evofolin B (1), （1S, 2S, 4R）-trans-2-hydroxy-1,8-cineole-β-D-glucopyranoside (2), (2R, 3R)-4-methoxyl- distylin (3), 1, 2, 3, 4, 6-penta-galloyl-glucose (4), catechin (5), benzoic acid (6), gallic acid (7), vanillic acid (8), methyl gallate (9), progallin A (10). Compounds 1-3 were obtained from this genus for the first time. |
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| Keywords: | Paeonia albifloria chemical constituent structural identification ethanol extraction |
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