| 六配位R2SnCl2（N—N）型新配合物的合成及其体外抑癌活性 |
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| 引用本文： | 李青山,杨频.六配位R2SnCl2（N—N）型新配合物的合成及其体外抑癌活性[J].中国药物化学杂志,1999,9(4):297-302. |
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| 作者姓名： | 李青山 杨频 |
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| 作者单位： | [1]山西医科大学药学系 [2]山西大学分子所 |
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| 基金项目： | 国家科技部重点资助项目!(No.9690106038)，国家自然科学基金!资助项目(No.39900185) |
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| 摘 要： | 从８０年代初起，有机锡化合物的抗癌活性日益受到重视，研究人员合成了大量的有机锡化合物，并对其进行了较全面的抗癌活性筛选〔１～３〕．吡唑衍生物具有抗菌〔４，５〕和杀虫作用〔６〕，其结构中有多个配位点，本文合成了两个新的吡唑衍生物（见图１）并用其作为双氮螯合配体来合成数个六配位Ｒ２ＳｎＣｌ２（Ｎ（Ｎ）型新配合物，并对它们的结构进行了表征，考察了它们对多种癌细胞的抑制作用，探讨了构效关系，结果表明这些六配位Ｒ２ＳｎＣｌ２（Ｎ（Ｎ）型新配合物主要对Ｐ３８８淋巴白血病有较强的抑制作用．配体的合成配体Ｉ〔Ｎ…
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| 关 键 词： | 有机锡化合物 合成 抗癌活性 |
Synthesis,Characterization and Their In Vitro Antitumor Activity of Di n Butyl (or Phenyl)Dichloride Complexes with N(N Type Ligands |
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| Li Qingshan,Huang Jijun.Synthesis,Characterization and Their In Vitro Antitumor Activity of Di n Butyl (or Phenyl)Dichloride Complexes with N(N Type Ligands[J].Chinese Journal of Medicinal Chemistry,1999,9(4):297-302. |
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| Authors: | Li Qingshan Huang Jijun |
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| Abstract: | Four new diorganotin complexes were synthesized and characterized by IR and 1H NMR.Their in vitro antitumor activities against a series of human tumor cell lines such as P 388 tumor cells were tested.The results showed that the complexes mainly exhibited strong antitumor activities against P 388 ,but presented no activities against other tumor cell lines.The structure activity relationships were discussed. |
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| Keywords: | diorganotin complex synthesis antitumor activity |
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