| 微紫青霉对莪术醇的定向转化 |
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| 引用本文： | 张卉,邱峰,曲戈霞,姚新生.微紫青霉对莪术醇的定向转化[J].中国药物化学杂志,2005,15(5):305-306. |
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| 作者姓名： | 张卉 邱峰 曲戈霞 姚新生 |
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| 作者单位： | 1. 沈阳药科大学,中药学院,辽宁,沈阳,110016
2. 沈阳药科大学,中药学院,辽宁,沈阳,110016;深圳中药及天然药物研究中心,广东,深圳,518055 |
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| 摘 要： | 使用微紫青霉对莪术醇(1)进行生物转化,采用硅胶柱色谱法从发酵液的乙酸乙酯萃取层中分离得到转化产物(2),利用理化及各种光谱手段鉴定其结构为15-羟基莪术醇.微紫青霉对莪术醇具有定向转化能力,获得转化产物的收率为24%,该转化产物为未见文献报道的新化合物.利用二维核磁共振等手段对其碳、氢信号进行了全归属.体外试验表明:化合物2对副流感病毒、呼吸道合孢病毒和单纯疱疹病毒I型具有较好的抑制作用.
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| 关 键 词： | 药物化学 生物转化 莪术醇 微紫青霉 抗病毒活性 |
| 文章编号： | 1005-0108（2005）05-0305-02 |
| 收稿时间： | 2005-06-03 |
| 修稿时间： | 2005-06-03 |
The directional biotransformation of curcumol by Penicillium janthinellum |
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| ZHANG Hui,QIU Feng,QU Ge-xia,YAO Xin-sheng.The directional biotransformation of curcumol by Penicillium janthinellum[J].Chinese Journal of Medicinal Chemistry,2005,15(5):305-306. |
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| Authors: | ZHANG Hui QIU Feng QU Ge-xia YAO Xin-sheng |
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| Abstract: | The directional biotransformation of curcumol(1) by Penicillium janthinellum was studied.The metabolite(2) was isolated by silica gel column chromatography and purified by recrystallization.Its structure was elucidated as 15-hydroxy curcumol on the basis of chemical and spectroscopic methods.Penicillium janthinellum has the ability to transform curcumol directly.The metabolite was characterized as a new compound.The carbon and proton signals were assigned by means of 2D spectroscopy.Compound 2 shows anti-virus activity in vitro. |
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| Keywords: | medicinal chemistry hiotransformation curcumol Penicillium janthinellum anti-virus activity |
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