| 一株耐碱链霉菌次生代谢产物的研究 |
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| 引用本文： | 郑丹,姜怡,娄恺,陈云,徐丽华,韩力.一株耐碱链霉菌次生代谢产物的研究[J].中国药物化学杂志,2009,19(5):375-378. |
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| 作者姓名： | 郑丹 姜怡 娄恺 陈云 徐丽华 韩力 |
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| 作者单位： | 1．中国医科大学 药学院，辽宁 沈阳 110001；2．云南大学 教育部微生物资源开放研究重点实验室，云南 昆明 650091；3．新疆农业科学院 微生物研究所 特殊环境微生物资源重点实验室，新疆 乌鲁木齐 830000 |
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| 摘 要： | 目的 研究一株耐碱链霉菌（Streptomyces pleomorphus sp. nov.）发酵液乙酸乙酯提取物的化学成分。方法 采用硅胶柱色谱，凝胶柱色谱方法进行分离纯化，利用波谱分析法结合理化性质确定化合物结构。结果 从S. pleomorphus sp. nov.发酵液的乙酸乙酯萃取物中分离得到9个已知化合物，分别鉴定为路易斯安那碱A （1）、路易斯安那碱B （2）、4，7-二羟基异黄酮（3）、4，7-二羟基-6-甲氧基异黄酮（4）、4，5，7-三羟基异黄酮（5）、14-甲基十五烷酸（6）、（E）-3-甲硫基-丙烯酸（7）、4-羟基苯乙醇（8）、β-谷甾醇（9）。结论 9个化合物均为首次从S. pleomorphus sp. nov.代谢产物中分离得到。
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| 关 键 词： | 链霉菌 次生代谢产物 结构鉴定 柱色谱法 |
| 收稿时间： | 2008-10-15 |
| 修稿时间： | 2009-6-16 |
Secondary metabolites from the broth of an alkalophilic streptomycete |
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| ZHENG Dan,JIANG Yi,LOU Kai,CHEN Yun,XU Li-hua,HAN Li.Secondary metabolites from the broth of an alkalophilic streptomycete[J].Chinese Journal of Medicinal Chemistry,2009,19(5):375-378. |
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| Authors: | ZHENG Dan JIANG Yi LOU Kai CHEN Yun XU Li-hua HAN Li |
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| Institution: | 1. School of Pharmaceutical Sciences, China Medical University, Shenyang 110001, China; 2. The Key Laboratory for Microbial Resources of Ministry of Education, Yunnan University, Kunming 650091, China; 3. The Key Laboratory for Microbial Resources in Special Environments, Xinjiang Academy of Agriculture Science, Urumchi 830000, China |
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| Abstract: | Aim To study chemical constituents from EtOAc extracts of the broth of an alkalophilic streptomycete Streptomyces pleomorphus sp. nov. Methods The compounds were isolated by various chromatographic techniques and the structures were elucidated on the basis of spectral analysis. Results Nine compounds were obtained, and their structures were identified as louisianin A (1), louisianin B (2), 4,7-dihydroxyisoflavone (3), 4,7-dihydroxy-6-methoxyisoflavone (4), 4,5,7-trihydroxyisoflavone (5), 14-methylpentadecanoic acid (6), 3-methylthio-2-propenoic acid (7), 4-hydroxybenzene ethanol （8），β-sitosterol（9）. Conclusion All the compounds were isolated from the metabolites of S. pleomorphus sp. nov. for the first time. |
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| Keywords: | streptomycete secondary metabolites structural identification column chromatography |
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