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叔丁基苯哌嗪取代硫醚类化合物的合成及其抗变态、抗炎活性
引用本文:王立升,周永红,刘百里.叔丁基苯哌嗪取代硫醚类化合物的合成及其抗变态、抗炎活性[J].中国药物化学杂志,1999,9(4):1.
作者姓名:王立升  周永红  刘百里
作者单位:广西大学工业测试实验中心!南宁530004(王立升,周永红),沈阳药科大学制药系!沈阳110015(刘百里,计志忠)
摘    要:设计并合成了13 个未见文献报道的叔丁基苯哌嗪取代硫醚类目标化合物,并经元素分析、核磁共振氢谱及红外光谱确证其化学结构.对部分目标化合物进行了抗变态和抗炎等生物活性测定.结果表明:W01 ,W03 ,W07 和W09 具有较强的抗变态活性

关 键 词:叔丁基苯哌嗪取代硫醚类衍生物  抗变态  抗炎
修稿时间::1999-08-0

Synthesis and Antiallergic,Antiinflammatory activities of Substituted t Butylphenylpiperazinylthio ether Derivatives
Wang Lisheng,Zhou Yonghong.Synthesis and Antiallergic,Antiinflammatory activities of Substituted t Butylphenylpiperazinylthio ether Derivatives[J].Chinese Journal of Medicinal Chemistry,1999,9(4):1.
Authors:Wang Lisheng  Zhou Yonghong
Abstract:Thirteen substituted t butylphenylpiperazinylthio ether derivatives were designed and synthesized which were identified by IR, 1H NMR spectral and elemental analysis and had not been found in literature.Some of them were evaluated from the antiallergic and antiinflammatory tests.The results showed that W01,W03,W07and W09 had stronger antiallergic effects.
Keywords:substituted  t    butylphenylpiperazinylthio  ether derivatives  antiallergy  antiinflammation  
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