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Topoisomerase i inhibitors from theStreptomyces sp. strain KM86-9B isolated from a marine sponge |
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| Authors: | Hong Kum Lee Deuk-Soo Lee Junghyun Lim Jung Sun Kim Kwang Sik Im Jee H Jung |
| Institution: | (1) Microbiology Lab., Korea Ocean Research & Development Institute, 425-600 Ansan, Korea;(2) College of Pharmacy, Pusan National University, 609-735 Pusan, Korea;(3) Present address: Department of Horticulture Science, Kon-Kuk University, 143-701 Seoul, Korea |
| Abstract: | The crude extract ofStreptomyces sp. strain KM86-9B, isolated from a marine sponge, displayed significant inhibition on topoisomerase I activity. Investigation of the causative components by bioactivity-directed fractionation resulted in the isolation of a series of iso- and anteiso-fatty acids. |
| Keywords: | Topoisomerase I inhibitor Marine actinomycete Isofatty acids Anteiso-fatty acids Marine sponge |
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