比较氨磺必利与利培酮治疗精神分裂症的效果评价

目的：分析氨磺必利与利培酮治疗精神分裂症的临床效果和不良反应。方法精神分裂症患者130例，分为研究组和对照组，研究组65例予以氨磺必利治疗，对照组65例采用利培酮治疗，疗程共计8周，采用阳性与阴性症状量表（ PANSS）和副反应量表（TESS）评定其疗效和不良反应。结果研究组总有效率为83%，对照组总有效率为77%，两组间差异无统计学意义（P〉0.05）。8周末研究组和对照组PANSS总分值均显著下降（P〈0.05）；两组不良反应差异无统计学意义（ P〉0.05）。结论氨磺必利治疗精神分裂症疗效优于利培酮，且不良反应与利培酮相似。

Analysis of clinical effects and adverse reactions of amisulpride and risperidone in the treatment of schizophrenia

Objective To analyze clinical effects and adverse reactions of amisulpride and risperidone in the treatment of schizophrenia.Methods A total of 130 patients diagnosed with schizophrenia were divided into research group and control group. 65 cases in the research group were treated with amisulpride, and the other 65 cases in the control group were treated with risperidone. The course of treatment lasted for 8 weeks, and the positive and negative symptoms scale （PANSS） and adverse event scale （TESS） were applied to evaluate the clinical effects and adverse reactions.Results The total effective rate of the research group was 83%, and that of the control group was 77%. Difference between the two groups was not statistically significant （P〉0.05）. After 8 weeks, PANSS score values were significantly decreased both in the research group and the control group （P〈0.05）. There was no statistically significant difference in two groups between adverse reactions（P〉0.05）. Conclusion The clinical effect of amisulpride is better than risperidone in the treatment of schizophrenia, and they have similar adverse reactions.