垂体后叶素联合酚妥拉明治疗支气管扩张大咯血的临床效果分析

目的分析垂体后叶素联合酚妥拉明治疗支气管扩张大咯血的临床效果。方法回顾性选取100例支气管扩张大咯血患者,依据治疗方法不同分为常规治疗组和联合治疗组,各50例。常规治疗组患者给予常规治疗,联合治疗组在常规治疗基础上给予垂体后叶素联合酚妥拉明治疗。比较两组患者的临床疗效,治疗前后的生命体征、经皮血氧饱和度,出血天数、总出血量,不良反应发生情况。结果联合治疗组患者的治疗总有效率92.0%(46/50)显著高于常规治疗组的74.0%(37/50),差异具有统计学意义(P<0.05)。联合治疗组患者治疗前体温、呼吸频率、心率、舒张压、收缩压、经皮血氧饱和度分别为(38.6±1.4)℃、(43.5±7.2)次/min、(115.2±14.3)次/min、(55.2±9.2)mm Hg(1 mm Hg=0.133 kPa)、(85.2±11.2)mm Hg、(60.5±14.7)%,治疗后分别为(36.8±1.2)℃、(29.6±5.5)次/min、(85.2±10.1)次/min、(80.5±10.5)mm Hg、(110.3±10.3)mm Hg、(95.3±13.5)%;常规治疗组患者治疗前体温、呼吸频率、心率、舒张压、收缩压、经皮血氧饱和度分别为(38.3±1.9)℃、(44.3±7.5)次/min、(114.4±13.7)次/min、(55.0±9.5)mm Hg、(86.3±11.5)mm Hg、(61.5±14.9)%,治疗后分别为(37.3±1.2)℃、(34.2±5.6)次/min、(94.3±11.8)次/min、(66.5±9.7)mm Hg、(95.3±10.4)mm Hg、(85.5±12.6)%。两组患者治疗前体温、呼吸频率、心率、舒张压、收缩压、经皮血氧饱和度比较差异均无统计学意义(P>0.05);治疗后,两组患者的体温、呼吸频率、心率均低于本组治疗前,舒张压、收缩压、经皮血氧饱和度均高于本组治疗前,差异具有统计学意义(P<0.05);治疗后,联合治疗组患者体温、呼吸频率、心率均低于常规治疗组,舒张压、收缩压、经皮血氧饱和度均显著高于常规治疗组,差异具有统计学意义(P<0.05)。联合治疗组患者的出血天数(7.0±1.2)d显著短于常规治疗组的(10.4±1.5)d,总出血量(730.7±156.5)ml显著少于常规治疗组的(906.8±140.0)ml,差异具有统计学意义(P<0.05)。联合治疗组患者的不良反应发生率8.0%(4/50)显著低于常规治疗组的24.0%(12/50),差异具有统计学意义(P<0.05)。结论垂体后叶素联合酚妥拉明治疗支气管扩张大咯血的临床效果好。

Clinical effect of pituitrin combined with phentolamine in the treatment of bronchiectasis and massive hemoptysis

Objective To analyze the clinical effect of pituitrin combined with phentolamine in treatment of bronchiectasis and massive hemoptysis.Methods 100 patients with bronchiectasis and massive hemoptysis were retrospectively selected and divided into routine treatment group and combined treatment group based on their therapeutic methods,with 50 cases in each group.Patients in the routine treatment group received the routine treatment,and patients in the combined treatment group received pituitrin combined with phentolamine in addition to the routine treatment.The clinical efficacy,vital signs,percutaneous oxygen saturation,bleeding days,total bleeding volume and adverse reactions before and after the treatment were compared between the two groups.Results The overall efficacy of the combined treatment group was 92.0%(46/50),which was significantly higher than 74.0%(37/50) of the routine treatment group,and the difference was statistically significant(P<0.05).Before the treatment,the combined treatment group had the body temperature of(38.6±1.4) ℃,respiratory rate of(43.5±7.2) times/min,heart rate of(115.2±14.3) times/min,diastolic blood pressure of(55.2±9.2) mm Hg(1 mm Hg = 0.133 kPa),systolic blood pressure of(85.2±11.2) mm Hg and percutaneous oxygen saturation of(60.5±14.7)%;after the treatment,the combined treatment group had the body temperature of(36.8±1.2)℃,respiratory rate of(29.6±5.5) times/min,heart rate of(85.2±10.1) times/min,diastolic blood pressure of(80.5±10.5) mm Hg,systolic blood pressure of(110.3±10.3) mm Hg and percutaneous oxygen saturation of(95.3±13.5)%.Before the treatment,the routine treatment group had the body temperature of(38.3±1.9)℃,respiratory rate of(44.3±7.5) times/min,heart rate of(114.4±13.7) times/min,diastolic blood pressure of(55.0±9.5) mm Hg,systolic blood pressure of(86.3±11.5) mm Hg and percutaneous oxygen saturation of(61.5±14.9)%;after the treatment,the routine treatment group had the body temperature of(37.3±1.2)℃,respiratory rate of(34.2±5.6) times/min,heart rate of(94.3±11.8) times/min,diastolic blood pressure of(66.5±9.7) mm Hg,systolic blood pressure of(95.3±10.4) mm Hg and percutaneous oxygen saturation of(85.5±12.6)%.Before the treatment,the differences in body temperature,respiratory rate,heart rate,diastolic blood pressure,systolic blood pressure and percutaneous oxygen saturation between the two groups were not statistically significant(P>0.05).After the treatment,the body temperature,respiratory rate and heart rate of each group were lower than those before the treatment,the diastolic pressure,systolic pressure and percutaneous oxygen saturation were higher than those before the treatment,and the differences were statistically significant(P<0.05).After the treatment,the body temperature,respiratory rate and heart rate of the combined treatment group were lower than those of the routine treatment group,and the diastolic blood pressure,systolic blood pressure and percutaneous oxygen saturation of the combined treatment group were significantly higher than those of the routine treatment group,and the differences were statistically significant(P<0.05).The bleeding days of the combined treatment group was(7.0±1.2) d,which was significantly shorter than(10.4±1.5) d of the routine treatment group,and the total bleeding volume of the combined treatment group was(730.7±156.5) ml,which was significantly less than(906.8±140.0) ml of the routine treatment group;and the differences were statistically significant(P<0.05).The incidence of adverse reactions of the combined treatment group was 8.0%(4/50),which was significantly lower than 24.0%(12/50) of the routine treatment group.Conclusion Pituitrin combined with phentolamine has good clinical effects in the treatment of bronchiectasis and massive hemoptysis.