| 阿仑磷酸钠和辛伐他汀对体外培养成骨细胞的影响 |
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| 引用本文： | 崔维顶,魏新程,李煜明.阿仑磷酸钠和辛伐他汀对体外培养成骨细胞的影响[J].中国实用医药,2008,3(36):8-10. |
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| 作者姓名： | 崔维顶 魏新程 李煜明 |
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| 作者单位： | 1. 南京医科大学第一附属医院骨科,211166
2. 南京市市级机关医院骨科 |
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| 摘 要： | 目的探讨辛伐他汀和阿仑磷酸钠对体外培养成骨细胞的影响。方法分离3周龄成骨细胞，体外培养时以辛伐他汀和阿仑磷酸钠刺激，观察成骨细胞碱性磷酸酶水平和成骨细胞增殖率。结果辛伐他汀、阿仑磷酸钠可以促进成骨细胞增殖，增加碱性磷酸酶的分泌，二者共同作用后作用更显著。结论辛伐他汀和阿仑磷酸钠能促进成骨细胞增殖和分泌碱性磷酸酶，可以联合作用促进骨形成。
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| 关 键 词： | 辛伐他汀 阿仑磷酸钠 成骨细胞 |
Effect of alendronate sodium and simvastatin on osteoblasts cultured in vitro |
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| CUI Wei-ding,WEI Xin-cheng,LI Yu-ming.Effect of alendronate sodium and simvastatin on osteoblasts cultured in vitro[J].China Practical Medical,2008,3(36):8-10. |
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| Authors: | CUI Wei-ding WEI Xin-cheng LI Yu-ming |
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| Institution: | CUI Wei-ding,LI Yu-ming,WEI Xin-cheng.Department of Orthopedics,the First Affiliated Hospital of Nanjing Medical University,Jiangsu 211166,China |
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| Abstract: | Objective To study the effect of alendronate sodium and simvastatin on osteoblasts cultured in vitro.Methods Three weeks old SD rats osteoblasts were isolated,osteoblasts were stimulated with alendronate and simvastatin,proliferation ratio and alkaline phosphatase(ALP)activity were assessed.Results Alendronate sodium and simvastatin not only promoted proliferation of osteoblasts,but also stimulated ALP activity,combination of both drugs had a significant effect.Conclusion Alendronate sodium and simvastatin can promote proliferation and ALP activity of osteoblasts,which could be combinated to promote the form of bone. |
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| Keywords: | Simvastatin Alendronate sodium Osteoblast |
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