| 缺氧时TXA_2和PGI_2对心肌血流量变化的调节作用 |
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| 引用本文： | 周玉峰,黄梅,邓聪颖,汤立新.缺氧时TXA_2和PGI_2对心肌血流量变化的调节作用[J].中国实用医药,2010,5(12):48-49. |
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| 作者姓名： | 周玉峰 黄梅 邓聪颖 汤立新 |
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| 作者单位： | 重庆市解放军第三二四医院神经外科/重庆市重庆通信学院门诊部,400020 |
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| 摘 要： | 目的本文旨在探讨TXA2和PGI2在缺氧时对心肌血流量的调节作用。方法大鼠随机分为平原组和急性缺氧组,用99mTc标记蟾蜍红细胞测定心肌血流量,用放免法分别测量血栓素A2、前列环素的含量。结果急性缺氧导致左、右心室心肌血流量、血浆TXB2含量、TXB2/6-keto-PGF1浕比值明显增高（P〈0.05）,左、右心室心肌血管阻力明显下降（P〈0.05）,6-keto-PGF1浕无明显变化？崧邸〖毙匀？氧时,左、右心室心肌血流量增加,TXA2和PGI2参与了急性缺氧时心肌血流量的调节,以TXA2的缩血管作用为主。
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| 关 键 词： | 大鼠 缺氧 心肌血流量 血栓素A2 前列环素 |
Roles of thromboxane A_2 and prostacyclin regulation of myocardial bood flow during acute hypoxia |
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| ZHOU Yu-feng,Huang Mei,Deng Cong-ying,et al..Roles of thromboxane A_2 and prostacyclin regulation of myocardial bood flow during acute hypoxia[J].China Practical Medical,2010,5(12):48-49. |
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| Authors: | ZHOU Yu-feng Huang Mei Deng Cong-ying |
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| Institution: | ZHOU Yu-feng,Huang Mei,Deng Cong-ying,et al.Department of neurosurg,People\'s Liberation Army No.324 Hospital,Chongqing 400020,China.Department of clinic,Chongqing Communication Institute,Chongqing 400035,China |
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| Abstract: | Objective To investigate the roles of thromboxane A2（TXA2）and prostacyclin（PGI2）in regulation of myocardial blood flow（MBF）during acute hypoxia.MethodsRats were divided into normoxic group（Control）and acute hypoxia（AH）,MBF was measured with 99mTc radiolabelled toad RBC,the changes of plasm TXB2、6-keto-PGF1ɑ contents were observed.ResultsAcute hypoxia caused an increase in left and right ventricular MBF,plasm TXB2 contents and the ratio of TXB2/6-keto-PGF1ɑ,but plasm 6-keto-PGF1ɑ weren＇t changed,as compared with the control group.ConclusionTXA2 and PGI2 may be involved in the regulation of MBF in acute hypoxia,but the TXA2-dependent vasoconstriction is stronger than the PGI2-dependent. |
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| Keywords: | Rat Hypoxia Myocardial blood flow Thromboxane A2 Prostacyclin |
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