高血压病合并心律失常患者脂联素与心脏重构相关性研究

目的探讨高血压病及高血压合并心律失常患者血清脂联素水平，及其与心脏重构的相关性。方法选取原发性高血压病患者71例，分为单纯高血压组（36例）及合并心律失常组（35例）。测定血清脂联素水平、左室重量指数（LVMI）、左室内径、E／A比值，并进行相关性分析。结果合并心律失常组（0．977±0．340）mg／L]及单纯高血压病组（1．977±0．990）mg／L]脂联素浓度显著低于正常对照组（6．451±1．972）mg／L]（P〈0．01），合并心律失常组脂联素浓度显著低于单纯高血压组（P〈0．01）。合并心律失常组及单纯高血压组血清脂联素与左室重量指数（LVMI）、左室内径呈负相关。合并心律失常组与E／A比值呈正相关。结论高血压病患者，血清脂联素降低，合并心律失常的高血压患者降低更为显著。血清脂联素与心脏重构具有相关性。

Circulating adiponectin in relation to cardiac remodeling in hypertensive subjects with arrhythmia subjects

Objective To study the significance of variance in plasma adiponectin （APN） in hypertensive patients with arrhythmia, and the relationship between plasma APN and cardiac remodeling. Methods The study comprised 71 hypertensive subjects who were divided to 2 groups,35 of them were hypertension with arrhythmia, the other were simplex hypertensive subjects. The plasma APN, left ventricular mass index （ LVMI）, teft ventricular diastolic diameter（ LVDd）, E/A were determined. The relationship between them were tested. Results Plasma APN levels significantly decreased in both hypertension with arrhythmia group （0. 977 ±0. 340） mg/L ] and simplex hypertensive subjects （ 1. 977 ± 0. 990 ） mg/L ] than that in control （ 6.451 ± 1. 972）mg/L]. APN levels in hypertension with arrhythmia group significantly decreased than that in simplex In both hypertension with arrhythmia group and simplex hypertensive subjects, plasma adiponectin levels negatively correlated with LVMI and LVDd. Plasma adiponectin levels positively correlated with E/A in hypertension with arrhythmia group. Conclusions Plasma adiponectin decreased in simplex hypertensive subjects. The change was more significantly in hypertension with arrhythmia group. Plasma adiponectin was related to cardiac remodeling.