急性心肌梗死患者PCI术中应用全剂量替罗非班的临床效果观察

目的分析急性心肌梗死患者在经皮冠状动脉介入治疗(PCI)术中应用全剂量替罗非班的临床效果。方法84例接受PCI术治疗的急性心肌梗死患者,依据随机数字表法分为试验组与对照组,各42例。对照组患者PCI术中配合半剂量替罗非班治疗;试验组患者PCI术中配合全剂量替罗非班治疗。对比两组心功能改善情况、心血管不良事件发生率、心肌梗死溶栓试验(TIMI)血流分级。结果治疗后,试验组的左室舒张末期内径(LVEDD)(50.98±4.23)mm短于对照组的(58.01±4.88)mm,左室射血分数(LVEF)(58.41±3.28)%高于对照组的(53.00±3.19)%,差异有统计学意义(P<0.05)。两组心血管不良事件发生率比较,差异无统计学意义(P>0.05)。试验组TIMI血流分级3级占比高于对照组,差异有统计学意义(P<0.05);两组血流分级2级、1级、0级占比比较,差异无统计学意义(P>0.05)。结论急性心肌梗死患者PCI术治疗时配合应用全剂量替罗非班能够更好的促进患者术后心功能恢复,且并不会增加治疗期间的不良事件发生率,值得在临床上推广使用。

Observation on the clinical effect of full-dose tirofiban during PCI in patients with acute myocardial infarction

Objective To analyze the clinical effect of full-dose tirofiban during percutaneous coronary intervention(PCI)in patients with acute myocardial infarction.Methods A total of 84 patients with acute myocardial infarction undergoing PCI were divided into experimental group and control group according to the random numerical table,with 42 cases in each group.Patients in the control group were treated with half-dose tirofiban during PCI,while patients in the experimental group were treated with full-dose tirofiban during PCI.The improvement of cardiac function,incidence of adverse cardiovascular events,and thrombolysis in myocardial infarction(TIMI)flow grade classification were compared between the two groups.Results After treatment,the left ventricular end diastolic diameter(LVEDD)(50.98±4.23)mm of the experimental group was shorter than(58.01±4.88)mm of the control group,left ventricular ejection fraction(LVEF)(58.41±3.28)%of the experimental group were higher than(53.00±3.19)%of the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse cardiovascular events between the two groups(P>0.05).The proportion of TIMI flow grade 3 in the experimental group was higher than that in the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in the proportions of TIMI flow grade 2,grade 1,and grade 0 between the two groups(P>0.05).Conclusion The application of tirofiban during PCI in patients with acute myocardial infarction can better promote the recovery of postoperative cardiac function,and does not increase the incidence of adverse events during treatment,which is worthy of clinical promotion and application.