双倍剂量缬沙坦联合辛伐他汀对糖尿病肾病患者血清超敏C反应蛋白和脂联素的影响

目的探讨双倍剂量缬沙坦联合辛伐他汀对糖尿病肾病(DN)患者血清超敏C反应蛋白(hs-CRP)和脂联素的影响。方法 90例DN患者随机分为三组,各30例。所有患者均采用常规治疗,A组加用缬沙坦80mg,口服1次/d;B组加用缬沙坦160mg,口服1次/d;C组加用缬沙坦160mg口服1次/d,辛伐他汀20mg,口服1次/每晚。比较24h尿蛋白定量,血清hs-CRP和脂联素。结果三组的尿蛋白均有明显减少(P<0.05,P<0.01);B、C两组与A组治疗后有明显差异(P<0.05,P<0.01);C、B两组之间治疗后有明显差异(P<0.05)。治疗后三组的hs-CRP,脂联素均有明显减少(P<0.05,P<0.01);B、C两组与A组治疗后有明显差异(P<0.05);C、B两组之间治疗后有明显差异(P<0.05)。结论双倍剂量缬沙坦联合辛伐他汀可以减少DN患者hs-CRP和脂联素的表达,从而改善病情。

Double dose of valsartan plus simvastatin on the hs-CRP and adiponectin in patients with diabetic nephropathy

Objective To study the double dose of valsartan plus simvastatin on the high sensitivity C-reactive protein（hs-CRP） and adiponectin in patients with diabetic nephropathy.Methods Ninty patients with diabetic nephropathy were randomly divided into three groups,A group（n=30 cases）,B group（n=30 cases） and C group（n=30 cases）.They were treated thgough the conventional method.The patients in A group were be plus valsartan 80mg oral 1/day,in B group plus valsartan 160mg oral 1/day and in C group plus valsartan 160mg oral 1/day and simvastatin 20mg oral/per night.24-hour urinary protein excretion,hs-CRP and adiponectin were compared.Results 24-hour urinary protein excretion were decreased after treatment in all groups（P〈0.05,P〈0.01）.They were more significantly decreased in B and C groups than A group（P〈0.05,P〈0.01）.There was a significant difference between B and C group（P〈0.05）.Hs-CRP and adiponectin were decreased after treatment in all groups（P〈0.05,P〈0.01）.They were more significantly decreased in B and C groups than A group（P〈0.05）.There was a significant difference between B and C group（P〈0.05）.Conclusion Double dose of valsartan plus simvastatin can decrease hs-CRP and adiponectin in patients with DN,which can improve condition.